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Novobiocin sodium salt

Numéro de catalogue. AAJ6092809
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AAJ6092809 10 g
AAJ6092803 1 g
AAJ6092806 5 g
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Numéro de catalogue. AAJ6092809 Fournisseur Thermo Scientific Chemicals Code fournisseur J6092809
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Description

Novobiocin sodium salt, CAS # 1476-53-5, is a topoisomerase II inhibitor capable of inhibiting DNA synthesis. This compound is produced by Streptomyces nieveus and shows antibiotic activity. | CAS: 1476-53-5 | C31H35N2NaO11 | 634.61 g/mol

Topoisomerase II inhibitorNovobiocin sodium salt is effective an antistaphylococcal agent used in the treatment of Methicillin-resistant Staphylococcus aureus (MRSA). It is also used to inhibit the activity of retroviral RNA-dependent DNA polymerase as well as inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Novobiocin sodium salt, first isolated from Streptomyces nieveus, is a topoisomerase II inhibitor. It is a coumarin compound showing antibiotic activity
• Novobiocin sodium salt can inhibit DNA synthesis by inhibiting the topoisomerase II enzyme. Its antibacterial activity arises from competitive inhibition of the ATPase reaction catalyzed by the GyrB subunit

Application

• Novobiocin sodium salt is used to inhibit the activity of retroviral RNA-dependent DNA polymerase in laboratory experiments
• It is also used as an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase.
• Novobiocin sodium salt shows anti-staphylococcal activity against methicillin-resistant Staphylococcus aureus, a gram-positive bacterium
• It permits the relaxation of negative DNA supercoils and has been used to generate positively supercoiled DNA
• This compound inhibits the chaperone activity of Hsp90

Identifiants chimiques

CAS 1476-53-5
Molecular Formula C31H35N2NaO11
Molecular Weight (g/mol) 634.61
MDL Number MFCD00066541,MFCD00066541
InChI Key AXOUUAINTJNFRS-UHFFFAOYNA-N
PubChem CID 131673945
IUPAC Name sodium 7-{[4-(carbamoyloxy)-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl]oxy}-3-[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamido]-8-methyl-2,4-dioxo-3,4-dihydro-2H-1-benzopyran-3-ide
SMILES [Na+].COC1C(OC(N)=O)C(O)C(OC2=CC=C3C(=O)[C-](NC(=O)C4=CC=C(O)C(CC=C(C)C)=C4)C(=O)OC3=C2C)OC1(C)C

Spécifications

Type Novobiocin Sodium Salt
Physical Form Powder
Melting Point 215°C
Color Brown to White
Quantity 10 g
Beilstein 3892910
Merck Index 14,6722
Solubility Information Soluble in water at 100mg/ml; Also soluble in ethanol or DMSOSoluble in water,ethanol,dimethyldulfoxide and methanol.
Formula Weight 634.61
Chemical Name or Material Novobiocin Sodium Salt

Sécurité et manipulation

Hazard Category Warning
Hazard Statement GHS H Statement
H319-H317
Causes serious eye irritation.
May cause an allergic skin reaction.
Precautionary Statement GHS P Statement
P261-P280-P305+P351+P338-P363-P321-P501a
Avoid breathing dust/fume/gas/mist/vapors/spray.
Wear protective gloves/protective clothing/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Wash contaminated clothing before reuse.
Specific treatment (see label).
Dispose of contents/container in accordance with local/regional/national/international regulations.
EINECSNumber 216-023-6
RTECSNumber RD5425000
TSCA No
Recommended Storage Keep cold

RUO – Research Use Only