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Invitrogen™ Human IKBKE (IKK Epsilon), GST Tag Recombinant Protein

Numéro de catalogue. PR8031B
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PR8031B 100 μg
PV4875 10 μg
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Numéro de catalogue. PR8031B Fournisseur Invitrogen™ Code fournisseur PR8031B
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Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Full Length.

IKBKE is an activator of nuclear factor-kappa-B. Over expression of IKBKE has been observed in breast cancer cells, and suppression of IKBKE induces cell death. NF-kappa-B is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappa-B mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kappa-B is associated with Ikappa-B proteins in the cell cytoplasm, which inhibit NF-kappa-B activity. Ikappa-B is phosphorylated by Ikappa-B kinase (IKK) complex that contains IKK-a, IKK-b, and IKK-gamma. A novel molecule in the IKK complex was recently identified and designated IKK-iota/IKK-i. IKK epsilon is required for the activation of NF-kappa-B by PMA and T cell receptors but not by TNF-a and IL-1. IKK-iota/IKK-i message is expressed in a variety of tissues and is inducible by TNF-a, IL-1, and LPS.

Spécifications

Accession Number Q14164
Concentration See Label
For Use With (Application) Kinase Assay
Formulation 50mM tris with 50% glycerol, 2mM DTT, 0.02% polysorbate 20, 150mM NaCl, 0.5mM EDTA and no preservative; pH 7.5
Gene ID (Entrez) 9641
Molecular Weight (g/mol) 107.9 kDa
Name Human IKBKE (IKK Epsilon), GST Tag
pH Range 7.5
Purification Method Purified
Quantity 100 μg
Storage Requirements -80°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias AW558201; I-kappa-B kinase epsilon; Ikbke; IKKE; IKK-E; IKKepsilon; IKK-epsilon; IKKI; IKK-i; IKK-related kinase epsilon; inducible I kappa-B kinase; inducible IkappaB kinase; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; inhibitor of kappaB kinase epsilon; inhibitor of nuclear factor kappa-B kinase subunit epsilon; KIAA0151; RP11-534L20.1
Common Name IKK epsilon
Gene Symbol IKBKE
KinaseFamily IKK Kinase Family
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag GST-tag
Sequence Full length
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Kinase Group Ser⁄Thr Kinases: Other
Shipping Condition Dry Ice
Expression System Insect cells
Protein Family Kinases & Inhibitors
Protein Form Recombinant, Full Length
Form Liquid
Research Category Signal Transduction
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