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Gibco™ Human IL-13 variant Recombinant Protein, PeproTech®

Numéro de catalogue. 20013A100UG
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Numéro de catalogue. Quantity
20013A100UG 100 μg
20013A10UG 10 μg
20013A1MG 1 mg
20013A250UG 250 μg
20013A2UG 2 μg
20013A500UG 500 μg
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Numéro de catalogue. 20013A100UG Fournisseur Gibco™ Code fournisseur LS20013A100UG
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Description

Recombinant Protein

PeproTech's genetic variant, termed Recombinant Human IL-13 Variant, is a mature 115 amino acid protein with a substitution of Q for R at position 113. The calculated molecular weight of Recombinant Human IL-13 Variant is 12.6 kDa. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta, TNF-alpha, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 are cross-species reactive. A variant of IL-13 shows enhanced functional activity compared with the wild type IL-13.

Spécifications

Accession Number P35225
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 3596
Molecular Weight (g/mol) 12.6 kDa
Name Human IL-13 variant
Quantity 100 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias IL-13; Interleukin
Common Name IL-13 variant
Gene Symbol IL13
Biological Activity This IL-13 analog shows a two fold increase, relative to wild type IL-13, in bioactivity as measured by the in vitro dose dependent activation of STAT6 and IL-13 dependent gene induction in transfected A201.1 cells. This analog has also been shown to exhibit increased in vivo activity compared to wild type IL-13, as measured by the induction of airway hyper-responsiveness.
Conjugate Unconjugated
Recombinant Recombinant
Sequence MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGQFN
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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