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MilliporeSigma™ Upstate p300, HAT Domain Recombinant Enzyme

Catalog No. 14418
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50 μg
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14418 50 μg
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Catalog No. 14418 Supplier MilliporeSigma™ Supplier No. 14418
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Description

Recombinant GST-fusion protein corresponding to amino acids 1066-1707 of human p300.

EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. p300 is related by sequence to CBP (CREB-binding protein [CREB: cyclic-AMP responsive element binding protein]), and like CBP can stimulate transcription through activation of CREB. This EP300 activity is specifically inhibited by the adenovirus oncoprotein E1A. EP300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF.

Specifications

For Use With (Application) Histone Acetyltransferase Assay (HAT)
Content And Storage -20°C for up to 6 months from the date of receipt
Source Expressed in E. coli
Quantity 50 μg