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  4. Invitrogen™ Human CDK1/Cyclin B, His Tag Recombinant Protein

Invitrogen™ Human CDK1/Cyclin B, His Tag Recombinant Protein

Numéro de catalogue. pv3292
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Numéro de catalogue. Quantity
PV3292 10 μg
PR4768C 100 μg
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Numéro de catalogue. PV3292 Fournisseur Invitrogen™ Code fournisseur PV3292
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Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Recombinant, Full Length.

Cyclin-dependent kinase 1 (CDK1) and its regulatory partner Cyclin B are fundamental to the control of cell cycle transitions, specifically the G2/M phase transition, which ultimately leads to cell division. CDK1, a serine/threonine kinase, forms a complex with Cyclin B necessary for the initiation of mitosis. This complex phosphorylates various substrates to facilitate structural changes required for mitosis. The CDK1/Cyclin B complex is tightly regulated through a series of phosphorylation and dephosphorylation events that control its activation state. The nuclear-cytoplasmic shuttling of Cyclin B1, coupled with CDK1 activity, is crucial for proper mitotic entry and progression. Interestingly, CDK1/Cyclin B1 also plays a role in the coordination of mitochondrial bioenergetics, indicating a broader role in cell metabolism and division. Allosteric modifications, such as acetylation of specific lysine residues, notably lysine-33, also influence CDK1/Cyclin B interaction and function, emphasizing the intricate regulatory mechanisms governing their activity.

Spécifications

Accession Number P06493, P14635
Concentration See Label
For Use With (Application) Kinase Assay
Formulation 20mM tris with 0.5mM EDTA, 2mM DTT, 150mM NaCl, 0.01% Triton X-100, 20% glycerol and no preservative; pH 7.5
Gene ID (Entrez) 891, 983
Molecular Weight (g/mol) 91 kDa
Name Human CDK1/Cyclin B, His Tag
pH Range 7.5
Purification Method Purified
Quantity 10 μg
Storage Requirements -80°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias 5363; ABL1; cdc; CDC2; cdc-2; cdc2 kinase; CDC28A; Cdc2a; cdc2-a; cdc2Dm; cdc2 x 1.1; CDCDm; CDK1; Cdk-1; cdk1.S; CDK1/CDC2; CDK1-A; cdk1-b; Cdk1-PA; CDKN1; cell cycle controller CDC2; cell cycle p34 CDC2 kinase protein; cell division control; cell division control protein 2 homolog; Cell division control protein 2 homolog 1; cell division control protein 2-A; cell division cycle 2 homolog A; cell division cycle 2 like; cell division cycle 2, G1 to S and G2 to M; Cell division cycle control protein 2; cell division cycle control protein 2 A; cell division protein kinase 1; Cell division protein kinase 1-A; CG5363; CG5363-PA; cyclin dependent kinase; cyclin dependent kinase 1; cyclin-dependent kinase; Cyclin-dependent kinase 1; cyclin-dependent kinase 1 S homeolog; cyclin-dependent kinase 1-A; D2366; Dcdc2; dCdk1; DKFZp686L20222; Dm cdc2; Dmcdc2; DmCdk1; Dmel\CG5363; Dmel_CG5363; DNA polymerase delta catalytic subunit; DNA polymerase III; DNA-directed DNA polymerase delta POL3; group 4; HPR6; KCIP-1; l(2)31 Eh; LD38718p; maturation-promoting factor; MGC111195; MGC53829; MPF; OTTHUMP00000019660; P34 CDK1; P34 MGC111195; p34 protein kinase; p34 protein kinase 1; p34cdc2; p34-cdc2 homologue; POL3; Protein 1054; protein 2; PSTAIR; TE x 1; unnamed protein product; xcdc2; XELAEV_18036802mg; YDL102W
Common Name CDK1/Cyclin B
Gene Symbol CCNB1, CDK1
KinaseFamily CDK and CHK Kinase Family
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-tag
Sequence Full length
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Assay Entry Biochemical binding/kinetic, Biochemical phospho-specific activity (no antibody)
Kinase Group Ser⁄Thr Kinases: CMCG Group
Shipping Condition Dry Ice
System Compatibility Z'-LYTE™, Omnia™ Bulk Substrate
Target Entry CDK1
Target Gene cyclin-dependent kinase 1
Expression System Insect cells
Protein Family Kinases & Inhibitors
Protein Form Recombinant, Full Length
Form Liquid
Protein Subtype Serine/Threonine Kinases
Research Category Cell Cycle & Proliferation, Signal Transduction
Purity or Quality Grade 80% by SDS-PAGE
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