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MilliporeSigma™ Calbiochem™ Emetine, Dihydrochloride
Principal alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha.
Supplier: MilliporeSigma™ 324693250MG
Description
Principal alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha . Irreversibly blocks protein synthesis in eukaryotes by inhibiting the movement of ribosomes along the mRNA. Induces hypotension by blocking adrenoreceptors. Interferes with cytometric analysis of DNA replication at the early S phase. Also identified as a specific inhibitor of HIF-2α protein stability and transcriptional activity (IC50 ≤1μM.Specifications
| White with a Faint Yellow Cast | |
| Movement of ribosomes along the mRNA | |
| C29H40N2O4·2HCl | |
| EtOH or H2O | |
| Solid |
| 98% by HPLC and Titration (dried basis) (perchloric acid method) | |
| 316-42-7 | |
| 553.6g/mol | |
| Hygroscopic, Protect from light | |
| 250 mg |