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Invitrogen™ Viperin Polyclonal Antibody
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Numéro de catalogue. PIPA565556
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100 μL
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Numéro de catalogue. Quantity
PIPA565556 100 μL
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Numéro de catalogue. PIPA565556 Fournisseur Invitrogen™ Code fournisseur PA565556

Description

Rabbit Polyclonal Antibody

Immunogen sequence: YLDILAISCDS FDEEVNVLIG RGQGKKNHVE NLQKLRRWCR DYRVAFKINS VINRFNVEED MTEQIKALNP VRWKVFQCLL IEGENCGEDA L Highest antigen sequence identity to the following orthologs - mouse 91%, rat 91%.

Viperin is a 43kDa protein which is one of several hundred interferon inducible viral proteins. Elevated expression of viperin is induced by LPS and poly I:C through TLR dependent signaling pathways. Sendai virus mediated viperin expression is induced independently of TLR signaling pathways through RLRs - RIG-I and MAVs (Severa, 2006). Viperin has been shown to play an important role in interferon mediated anti-viral activity in a Hepatitis C virus model system (Helbig, 2011). Viperin is induced in lymphoid cells and dendritic cells (DCs) and highly induced in neutrophils and macrophages during acute LCMV infection in mice (Hinson, ). Viperin functions as a mediator of viral resistance and as a marker for interferon responsiveness making its detection and mechanism of action through specific antibody probes valuable for further studies.

Spécifications

Antigen Viperin
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Rsad2
Gene Accession No. Q8WXG1
Gene Alias 2510004L01Rik; Best5; Bone-expressed sequence tag 5 protein; cig33; cig5; CIG6; cytomegalovirus-induced gene 5 protein; hypothetical protein LOC570456; inflammatory response gene 6 protein; inflammatory response protein 6; IRG6; radical S-adenosyl methionine domain containing 2; radical S-adenosyl methionine domain-containing protein 2; rsad2; rsad2 {ECO:0000250; si:ch211-276e8.2; similar to radical S-adenosyl methionine domain containing 2; UniProtKB:Q8WXG1}; VHSV-induced-like protein; Vig1; Viperin; viral hemorrhagic septicemia virus (VHSV)-induced gene 1; virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible; zgc:112342
Gene Symbols Rsad2
Host Species Rabbit
Immunogen Recombinant Human Viperin. Recombinant protein control fragment (Product #RP-106231).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 91543
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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