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Tocris Bioscience™ Triptolide

Catalog No. 325310
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325310 10 mg
32531 1 mg
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Catalog No. 325310 Supplier Tocris Bioscience™ Supplier No. 3253/10
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Description

Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive

Triptolide inhibits DNA-dependent ATPase activity of XBP and induces inhibition of RNA polymerase II (RNAPII)-mediated transcription (IC50 = 200 nM). Selective for RNAPII over RNAPI and RNAPIII. Triptolide blocks RNA synthesis in HeLa cells (IC50 = 62 nM); exhibits potent antiproliferative activity in 60 cancer cell lines (average IC50 = 12 nM) and induces apoptosis by blocking TNF-α-mediated c-IAP1 and c-IAP2 induction. Also displays immunosuppressive and anti-inflammatory activity.

Chemical Identifiers

CAS 38748-32-2
Molecular Formula C20H24O6

Specifications

Quantity 10 mg
Formula Weight 360.4
Purity >98%
Molecular Weight (g/mol) 360.41
Chemical Name or Material Triptolide

Safety and Handling

Recommended Storage Store at -20°C