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  8. Triethyl methanetricarboxylate, 98%

Triethyl methanetricarboxylate, 98%

Numéro de catalogue. AAL0835614
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25 g
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AAL0835614 25 g
AAL0835606 5 g
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Numéro de catalogue. AAL0835614 Fournisseur Thermo Scientific Chemicals Code fournisseur L0835614
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Description

CAS: 6279-86-3 | C10H16O6 | 232.232 g/mol

Methanetricarboxylates have been used as blocked malonic esters, restricting reaction with alkyl halides to monoalkylation. The unwanted carboxyl group can be removed by treatment with Na alkoxide, LDA or BCl3. Provides a useful 2-carbon chain extension method that adds to Michael acceptors under phase-transfer conditions. Triethyl Methanetricarboxylate is used in the synthesis of novel inhibitors of Hsp90. It is also used in the preparation of novel dihydroquinoline-3-carboxylic acids that function as HIV-1 integrase inhibitors.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Methanetricarboxylates have been used as ″blocked″ malonic esters, restricting reaction with alkyl halides to monoalkylation. The unwanted carboxyl group can be removed by treatment with Na alkoxide, LDA or BCl3. Provides a useful 2-carbon chain extension method that adds to Michael acceptors under phase-transfer conditions. Triethyl Methanetricarboxylate is used in the synthesis of novel inhibitors of Hsp90. It is also used in the preparation of novel dihydroquinoline-3-carboxylic acids that function as HIV-1 integrase inhibitors.

Solubility
Insoluble in water.

Notes
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Identifiants chimiques

CAS 6279-86-3
Molecular Formula C10H16O6
Molecular Weight (g/mol) 232.232
MDL Number MFCD00009150
InChI Key AGZPNUZBDCYTBB-UHFFFAOYSA-N
Synonym tricarbethoxymethane, triethylmethanetricarboxylate, methanetricarboxylic acid, triethyl ester, 2-ethoxycarbonyl-malonic acid diethyl ester, methanetricarboxylic acid triethyl ester, carboxymalonic acid triethyl ester, diethyl 2-ethoxycarbonyl malonate, diethyl 2-ethoxycarbonyl propane-1,3-dioate, pubchem3106, triethoxycarbonylmethane
PubChem CID 80471
IUPAC Name triethyl methanetricarboxylate
SMILES CCOC(=O)C(C(=O)OCC)C(=O)OCC

Spécifications

Melting Point 26°C to 29°C
Density 1.095
Boiling Point 253°C
Flash Point >110°C (230°F)
Refractive Index 1.4255
Quantity 25 g
Beilstein 1793645
Solubility Information Insoluble in water.
Formula Weight 232.23
Percent Purity 98%
Chemical Name or Material Triethyl methanetricarboxylate
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Sécurité et manipulation

EINECSNumber 228-477-2
TSCA No
Recommended Storage Ambient temperatures

RUO – Research Use Only