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Invitrogen™ SDHD Polyclonal Antibody
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Numéro de catalogue. PIPA571645
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Quantité:
400 μL
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Numéro de catalogue. Quantité
PIPA571645 400 μL
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Numéro de catalogue. PIPA571645 Fournisseur Invitrogen™ Code fournisseur PA571645

Description

Rabbit Polyclonal Antibody

SDHD Polyclonal Antibody for Western Blot, ICC/IF, IHC (P), Flow

The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.

Spécifications

Antigène SDHD
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugué Unconjugated
Formule PBS with 0.09% sodium azide; pH 7.4
Gène SDHD
Numéro d’acquisition du gène O14521
Alias du gène 3110001M13Rik; AVLL5809; C78570; CBT1; CII-4; CWS3; CybS; PGL; PGL1; PRO19626; QPs3; SDH4; SDHD; Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; succinate dehydrogenase complex subunit D; succinate dehydrogenase complex subunit D integral membrane protein; succinate dehydrogenase complex, subunit D, integral membrane protein; succinate-ubiquinone oxidoreductase cytochrome b small subunit; Succinate-ubiquinone reductase membrane anchor subunit
Symboles de gène SDHD
Espèces hôtes Rabbit
Immunogène KLH conjugated synthetic peptide between 13-42 amino acids from the N-terminal region of human SDHD.
Méthode de purification Antigen affinity chromatography, Protein A
Quantité 400 μL
Statut réglementaire RUO
Primaire ou secondaire Primary
ID du gène (Entrez) 6392
Espèces cibles Human
Contenu et stockage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Type de produit Antibody
Forme Liquid
Isotype IgG
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