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Invitrogen™ RIP1 Recombinant Superclonal™ Antibody

Numéro de catalogue. 711689
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100 μg
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Numéro de catalogue. Quantité
711689 100 μg
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Numéro de catalogue. 711689 Fournisseur Invitrogen™ Code fournisseur 711689

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Description

Rabbit Recombinant Superclonal Antibody

This antibody is predicted to react with Monkey, Horse, Cat Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called 'Recombinant polyclonal antibody', this product is now rebranded as 'Recombinant Superclonal™ antibody'. The physical product and the performance remain unchanged.

Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.

Spécifications

Antigène RIP1
Applications Western Blot, Immunocytochemistry
Classification Recombinant Superclonal
Concentration 0.5 mg/mL
Conjugué Unconjugated
Formule PBS with 0.09% sodium azide; pH 7.2-7.4
Gène RIPK1
Numéro d’acquisition du gène Q13546
Alias du gène cell death protein RIP; D330015H01Rik; FLJ39204; OTTHUMP00000015955; receptor (TNFRSF)-interacting serine-threonine kinase 1; receptor interacting serine/threonine kinase 1; receptor-interacting protein 1; receptor-interacting protein kinase 1; receptor-interacting serine/threonine-protein kinase 1; Rinp; RIP; RIP1; RIP-1; RIP1 (CT); RIPK1; serine/threonine-protein kinase RIP
Symboles de gène RIPK1
Espèces hôtes Rabbit
Immunogène Protein corresponding to human RIPK1 [aa1-aa294].
Méthode de purification Protein A
Quantité 100 μg
Statut réglementaire RUO
Primaire ou secondaire Primary
ID du gène (Entrez) 8737
Espèces cibles Human
Contenu et stockage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Type de produit Antibody
Forme Liquid
Isotype IgG
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