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  5. Tocris Bioscience™ Purmorphamine

Tocris Bioscience™ Purmorphamine

Catalog No. 455150
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455150 50 mg
455110 10 mg
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Catalog No. 455150 Supplier Tocris Bioscience™ Supplier No. 4551/50
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Description

Smo receptor agonist

Purmorphamine is a smoothened (Smo) receptor agonist (EC50 ∼ 1 μM) and activates the Hedgehog pathway. Purmorphamine induces osteogenesis in mouse mesenchymal progenitor cells (C3H10T1/2). When combined with BMP-4, Purmorphamine can transdifferentiate pre-adipocytes (3T3-L1) and myoblasts (C2C12) into osteoblasts. Purmorphamine induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts, and of spinal motor neurons from pluripotent human stem cells, and protects dopaminergic neurons in a mouse model of Parkinson's disease.

Chemical Identifiers

CAS 483367-10-8
Molecular Formula C31H32N6O2

Specifications

Quantity 50 mg
Formula Weight 520.62
Molecular Weight (g/mol) 520.637
Chemical Name or Material Purmorphamine

Safety and Handling

Recommended Storage Store at -20°C