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Invitrogen™ POMGNT1 Polyclonal Antibody
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Numéro de catalogue. PIPA5100281
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Quantité:
100 μL
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Numéro de catalogue. Quantité
PIPA5100281 100 μL
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Numéro de catalogue. PIPA5100281 Fournisseur Invitrogen™ Code fournisseur PA5100281

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total MGAT1.

The product of the POMGNT1 gene, protein O-mannose beta-1,2-N-acetylglucosaminyltransferase, participates in O-mannosyl glycan synthesis. POMGnT1 is an N(in)/C(out) (type II) membrane protein localized in the medial-Golgi that initiates the conversion of high mannose N-glycans to complex N-glycans. Specifically, POMGnT1 is a glycosylation enzyme that participates in the synthesis of O-mannosyl glycan, a laminin-binding ligand of alpha-dystroglycan that is rarely synthesized in mammals. Mutations in the POMGNT1 gene cause muscle-eye-brain disease (MEB), an autosomal recessive disorder characterized by congenital muscular dystrophy, ocular abnormalities and lissencephaly.

Spécifications

Antigène POMGNT1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugué Unconjugated
Formule PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gène POMGNT1
Numéro d’acquisition du gène Q5XIN7, Q8WZA1, Q91X88
Alias du gène 0610016I07Rik; 4930467B06Rik; GnT I.2; GNTI.2; gnT-I.2; LGMD2O; MDDGA3; MDDGB3; MDDGC3; MEB; MGAT1.2; N-acetylglucosaminyltransferase I.2; O-linked mannose beta1,2-N-acetylglucosaminyltransferase; O-mannosyl N-acetylglucosaminyltransferase; OMGnT1; POMGNT1; protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase; protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase; protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-); protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1; protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1; LOW QUALITY PROTEIN: protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1; RP11-322N21.3; UDP-GlcNAc:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2; UNQ746/PRO1475
Symboles de gène POMGNT1
Espèces hôtes Rabbit
Immunogène A synthesized peptide derived from human POMGNT1(Accession Q8WZA1), corresponding to amino acid residues L622-T660.
Méthode de purification Affinity Chromatography
Quantité 100 μL
Statut réglementaire RUO
Primaire ou secondaire Primary
ID du gène (Entrez) 362567, 55624, 68273
Espèces cibles Human, Mouse, Rat
Contenu et stockage -20°C
Type de produit Antibody
Forme Liquid
Isotype IgG
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