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Thermo Scientific™ LC-SPDP (succinimidyl 6-(3(2-pyridyldithio)propionamido)hexanoate)
Crosslink amines to sulfhydryls with this crosslinker composed of NHS-ester and pyridyldithiol groups at ends of 10-atom (15.7A) spacer arm.
Supplier: Thermo Scientific™ 21651
Description
Thermo Scientific™ Pierce LC-SPDP is a long-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.
Highlights:
- Forms cleavable disulfide bonds with sulfhydryls
- Releases a detectable byproduct after reacting with a free sulfhydryl group; by measuring the release of pyridine-2-thione at 343nm, the reaction can be monitored
- Reactive groups: NHS ester and pyridyldisulfide
- Reactive toward: amino and sulfhydryl groups
Specifications
| Amine-Sulfhydryl | |
| LC-SPDP | |
| No | |
| Upon receipt store at 4°C protected from moisture. | |
| Ambient | |
| Chemical Labeling | |
| NHS Ester, Pyridyldisulfide | |
| Powder | |
| DMF, DMSO | |
| No |
| By Thiols | |
| 425.52 | |
| 15.7 AÌ | |
| Yes | |
| Pierce | |
| Heterobifunctional | |
| Medium (10 to 30 AÌ) | |
| 50 mg | |
| Standard | |
| Crosslinker |
For Research Use Only. Not for use in diagnostic procedures.