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Thermo Scientific™ LC-SPDP (succinimidyl 6-(3(2-pyridyldithio)propionamido)hexanoate)

Catalog No. PI21651
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Quantity:
50 mg
Catalog No. Quantity
PI21651 50 mg
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Catalog No. PI21651

Supplier: Thermo Scientific™ 21651

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Description

Crosslink amines to sulfhydryls with this crosslinker composed of NHS-ester and pyridyldithiol groups at ends of 10-atom (15.7A) spacer arm.

Thermo Scientific™ Pierce LC-SPDP is a long-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.

Highlights:

  • Forms cleavable disulfide bonds with sulfhydryls
  • Releases a detectable byproduct after reacting with a free sulfhydryl group; by measuring the release of pyridine-2-thione at 343nm, the reaction can be monitored
  • Reactive groups: NHS ester and pyridyldisulfide
  • Reactive toward: amino and sulfhydryl groups

Specifications

Chemical Reactivity Amine-Sulfhydryl
Cleavable By Thiols
Description LC-SPDP
Molecular Weight (g/mol) 425.52
PEGylated No
Spacer Arm Length 15.7 Å
Content And Storage Upon receipt store at 4°C protected from moisture.
Cell Permeability Yes
Shipping Condition Ambient
Product Line Pierce
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Reactive Moiety NHS Ester, Pyridyldisulfide
Spacer Medium (10 to 30 Å)
Form Powder
Quantity 50 mg
Solubility DMF, DMSO
Format Standard
Water Soluble No
Product Type Crosslinker
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For Research Use Only. Not for use in diagnostic procedures.