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Invitrogen™ Phospho-SMAD2/SMAD3 (Ser465, Ser467, Ser423, Ser425) Polyclonal Antibody
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Numéro de catalogue. PIPA5110155
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Quantité:
100 μL
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Numéro de catalogue. Quantité
PIPA5110155 100 μL
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Numéro de catalogue. PIPA5110155 Fournisseur Invitrogen™ Code fournisseur PA5110155

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Description

Rabbit Polyclonal Antibody

Phospho-SMAD2/SMAD3 (Ser465, Ser467, Ser423, Ser425) Polyclonal Antibody for ELISA, ICC/IF, IHC (P), Western Blot

Smad proteins, the mammalian homologs of the Drosophila mothers against decapentaplegic (Mad), have been implicated as downstream effectors of TGFβ/BMP signaling. Smad1 (also designated Madr1 or JV4-1) and Smad5 are effectors of BMP-2 and BMP-4 function, while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFβ and Activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to Activin/TGFβ signaling by interfering with TGFβ-mediated phosphorylation of other Smad proteins.

Spécifications

Antigène Phospho-SMAD2/SMAD3 (Ser465, Ser467, Ser423, Ser425)
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugué Unconjugated
Formule PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gène SMAD3
Numéro d’acquisition du gène O70436, P84025, Q62432, Q8BUN5
Alias du gène 7120426M23Rik; AU022421; hMAD-2; hMAD-3; hSMAD2; hSMAD3; HSPC193; HsT17436; JV15-2; JV18; JV18-1; LDS1C; LDS3; MAD (mothers against decapentaplegic, Drosophila) homolog 3; MAD homolog 2; MAD homolog 3; mad homolog JV15-2; mad protein homolog; MAD, mothers against decapentaplegic homolog 3; mad3; MADH2; MADH3; MADR2; mad-related protein 2; mMad2; mMad3; mother against DPP homolog 2; mothers against decapentaplegic homolog 2; Mothers against decapentaplegic homolog 3; mothers against DPP homolog 2; mothers against DPP homolog 3; pSMAD2; Sma- and Mad-related protein 2; SMA- and MAD-related protein 3; SMAD; Smad 2; Smad 3; SMAD family member 2; SMAD family member 3; SMAD, mothers against DPP homolog 2; SMAD, mothers against DPP homolog 3; Smad2; Smad-2; Smad3
Symboles de gène SMAD2, SMAD3
Espèces hôtes Rabbit
Immunogène Synthetic peptide.
Méthode de purification Affinity Chromatography
Quantité 100 μL
Statut réglementaire RUO
Primaire ou secondaire Primary
ID du gène (Entrez) 17126, 17127, 25631, 29357
Espèces cibles Mouse, Rat
Contenu et stockage -20°C, Avoid Freeze/Thaw Cycles
Type de produit Antibody
Forme Liquid
Isotype IgG
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