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  8. Phenylethyl 3,4-dihydroxycinnamate, 98+%

Phenylethyl 3,4-dihydroxycinnamate, 98+%

Numéro de catalogue. AAJ61386MD
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250 mg
1 g
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AAJ61386MD 250 mg
AAJ6138603 1 g
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Numéro de catalogue. AAJ61386MD Fournisseur Thermo Scientific Chemicals Code fournisseur J61386MD
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Description

Inhibitor of protein tyrosine kinase, and is cytotoxic to cancer cell lines | CAS: 104594-70-9 | C17H16O4 | 284.31 g/mol

Phenylethyl 3,4-dihydroxycinnamate is a potent and specific inhibitor of nuclear transcription factor, NF-κB, activation. It has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation. It inhibits HIV-1 integrase and also inhibits proliferation of transformed cells. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Phenylethyl 3,4-dihydroxycinnamate is a potent and specific inhibitor of nuclear transcription factor, NF-κB, activation. It has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation. It inhibits HIV-1 integrase and also inhibits proliferation of transformed cells. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.

Solubility
Soluble in ethyl acetate at 50mg/ml. Soluble in DMSO and ethanol.

Notes
Light sensitive. Incompatible with oxidizing agents and heat.

Identifiants chimiques

CAS 104594-70-9
Molecular Formula C17H16O4
Molecular Weight (g/mol) 284.31
MDL Number MFCD00866470
InChI Key SWUARLUWKZWEBQ-VQHVLOKHSA-N
Synonym caffeic acid phenethyl ester, phenethyl caffeate, cape, capeee, phenethyl 3-3,4-dihydroxyphenyl acrylate, phenylethyl caffeate, unii-g960r9s5sk, caffeic acid phenylethyl ester, 2-phenylethyl caffeate, caffeic acid 2-phenylethyl ester
PubChem CID 5281787
ChEBI CHEBI:8062
IUPAC Name 2-phenylethyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
SMILES OC1=CC=C(\C=C\C(=O)OCCC2=CC=CC=C2)C=C1O

Spécifications

Melting Point 127°C to 129°C
Color White to Yellow
Quantity 250 mg
Sensitivity Light sensitive
Solubility Information Soluble in ethyl acetate at 50mg/ml; Soluble in DMSO and ethanol.
Formula Weight 284.31
Percent Purity ≥99%
Physical Form Crystalline Powder
Chemical Name or Material Phenylethyl 3,4-dihydroxycinnamate

Sécurité et manipulation

Hazard Category H315-H319-H335
Hazard Statement GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Precautionary Statement P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
RTECSNumber UD3334375
TSCA No
Recommended Storage Store at -20°C

RUO – Research Use Only