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Gibco™ PeproGMP® Human BMP-4 Recombinant Protein, PeproTech®

Numéro de catalogue. 01672608
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50 μg
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Numéro de catalogue. Quantité
01672608 50 μg
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Numéro de catalogue. 01672608 Fournisseur Gibco™ Code fournisseur GMP12005ET50UG

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Description

Recombinant Protein

PeproTech E.coli-derived Human BMP-4 is a fully active homodimeric protein consisting of two 107 amino acid subunits, which correspond to amino acids 303-408 of the full length BMP-4 precursor, as well as an N-terminal Methionine. The calculated molecular weight of Recombinant Human BMP-4 (E.coli-derived) is 24.2 kDa. Additional product information and specifications are provided on the Certificate of Analysis. Note: All PeproGMP® products are manufactured using animal-derived component free materials. Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter 1043 Ancillary Materials for Cell, Gene, and Tissue-Engineered Products. Product use statement: For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.

Spécifications

Numéro d'enregistrement P12644
À utiliser avec (application) Control, Western Blot Control, Bioactivity
Format Lyophilized
Formule Protein with no preservative
ID du gène (Entrez) 652
Poids moléculaire (g/mol) 24.2 kDa
Nom PeproGMP™ Human BMP-4
Méthode de purification Purified
Quantité 50 μg
Conditions de stockage -20°C or -80°C if preferred
Statut réglementaire GMP
Concentration en endotoxines ≤0.1 EU/μg
Alias du gène BMP; BMP2B; BMP-2B; Bmp2b1; Bmp2b-1; Bmp4; Bmp-4; BOMPR4A; Bone morphogenetic protein; Bone morphogenetic protein 2B; bone morphogenetic protein 4; bone morphogenetic protein 4 preproprotein; DVR4; Dvr-4; MCOPS6; OFC11; ZYME
Nom usuel BMP4
Symbole de gène BMP4
Activité biologique Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells.
Type de produit Protein
Conjugué Unconjugated
Recombinant Recombinant
Séquence MKKNKNCRRH SLYVDFSDVG WNDWIVAPPG YQAFYCHGDC PFPLADHLNS TNHAIVQTLV NSVNSSIPKA CCVPTELSAI SMLYLDEYDK VVLKNYQEMV VEGCGCR
Contenu et stockage -20°Cor to +80°C if preferred
Activité Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells.
Système d’expression E. coli
Forme Lyophilized
Grade de qualité ou de pureté ≥ 98% by SDS-PAGE gel and HPLC analyses.
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