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Invitrogen™ Osteopontin Polyclonal Antibody
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Numéro de catalogue. PIPA534579
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Quantité:
100 μg
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Numéro de catalogue. Quantité
PIPA534579 100 μg
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Numéro de catalogue. PIPA534579 Fournisseur Invitrogen™ Code fournisseur PA534579

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Description

Rabbit Polyclonal Antibody

A suggested positive control is human bladder tissue lysate. PA5-34579 can be used with blocking peptide PEP-1622.

Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D.

Spécifications

Antigène Osteopontin
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugué Unconjugated
Formule PBS with 0.02% sodium azide
Gène SPP1
Numéro d’acquisition du gène P08721, P10451, P10923
Alias du gène 2AR; 2b7; 44 kDa bone phosphoprotein; Apl-1; BNSP; Bone sialoprotein 1; Bone sialoprotein 1 (BSPI/BSP1); Bsp; BSPI; Calcium oxalate crystal growth inhibitor protein; CALPHA1 fusion; Early T lymphocyte activation 1 (ETA1); early T-lymphocyte activation 1; early T-lymphocyte activation 1 protein; Eta; ETA-1; HGNC:11255; immunoglobulin alpha 1 heavy chain constant region fusion protein; MGC110940; Minopontin; nephropontin; Op; Opn; Opnl; OSP; osteopontin; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; osteopontin-like protein; PSEC0156; Ric; Secreted phosphoprotein 1; secreted phosphoprotein 1 (osteopontin bone sialoprotein I early T lymphocyte activation 1); secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1); Secreted phosphoprotein 1 (SPP1); secreted phosphoprotein 1 variant 6; Sialoprotein (osteopontin); SPP1; SPP-1; SPP1/CALPHA1 fusion; unnamed protein product; urinar; urinary stone protein; Uropontin
Symboles de gène SPP1
Espèces hôtes Rabbit
Immunogène An 18 amino acid peptide near the amino terminus of human SPP1.
Méthode de purification Protein A
Quantité 100 μg
Statut réglementaire RUO
Primaire ou secondaire Primary
ID du gène (Entrez) 20750, 25353, 6696
Espèces cibles Human, Mouse, Rat
Contenu et stockage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Type de produit Antibody
Forme Liquid
Isotype IgG
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