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Invitrogen™ Oligomer A11 Polyclonal Antibody
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Numéro de catalogue. AHB0052
Encompass
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Quantité:
50 μg
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Numéro de catalogue. Quantité
AHB0052 50 μg
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Numéro de catalogue. AHB0052 Fournisseur Invitrogen™ Code fournisseur AHB0052

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Description

Rabbit Polyclonal Antibody

This antibody recognizes amino acid sequence-independent oligomers of proteins or peptides. A11 does not recognize monomers or mature fibers of proteins or peptides. A11 reacts with soluble AB42 oligomers and does not react with soluble low molecular weight AB40 or AB40 fibrils. A11 recognizes oligomeric species of several other amyloidogenic polypeptides including AB42, human insulin, prion, polyglutamine, lysozyme, alpha-synuclein and yeast prion Sup35. Oligomeric AB42 is recommended as a positive control, monomeric and fibrillar AB42 as negative controls.

Many degenerative diseases are known to be related to the accumulation of misfolded proteins called, amyloid fibrils. Soluble amyloid oligomers are considered as the principal pathogenic species which play an important role in the formation of amyloid fibrils; therefore, oligomers are involved in the pathogenesis of the many neurodegenerative diseases. This anti-oligomer antibody provides a facile means of assessing the significance of oligomers in disease pathogenesis.

Spécifications

Antigène Oligomer A11
Applications Dot Blot, ELISA, Immunohistochemistry, Neutralization, Western Blot
Classification Polyclonal
Concentration 1.0 mg/mL
Conjugué Unconjugated
Formule PBS with 0.1% sodium azide; pH 7.4
Gène INS
Numéro d’acquisition du gène P01308, P01322, P01325
Alias du gène Antioligomer A11; IDDM; IDDM1; IDDM2; ILPR; INS; Ins1; Ins-1; Ins2-rs1; Insulin; insulin 1; Insulin A chain; Insulin B chain; insulin I; insulin-1; Insulin-1 A chain; Insulin-1 B chain; IRDN; MODY10; preproinsulin; proinsulin
Symboles de gène INS, Ins1
Espèces hôtes Rabbit
Immunogène Synthetic molecular mimic of soluble oligomers.
Méthode de purification Purified
Quantité 50 μg
Statut réglementaire RUO
Primaire ou secondaire Primary
ID du gène (Entrez) 16333, 24505, 3630
Espèces cibles Human, Mouse, Rat
Contenu et stockage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Type de produit Antibody
Forme Liquid
Isotype IgG
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