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Tocris Bioscience™ Olaparib

Catalog No. 757910
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757910 10 mg
757950 50 mg
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Catalog No. 757910 Supplier Tocris Bioscience™ Supplier No. 7579/10
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Description

Potent PARP inhibitor

Olaparib is a potent PARP2 and PARP1 inhibitor (IC50 values are 1 and 5 nM, respectively). Olaparib abolishes PARP-1 activity at a concentration of 30-100 nM in SW620 cell lysates. BRCA1-deficient cell lines are hypersensitive to PARP inhibition by Olaparib in comparison with BRCA1- and BRCA2-proficient cells. Olaparib potentiates the antitumor activity of the methylating chemotherapeutic agent Temozolomide (Cat. No. 2706) in xenograft mouse model. Olaparib is orally bioavailable in rats.

Specifications

Chemical Name or Material 4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2 H)-phthalazinone
CAS 763113-22-0
Quantity 10 mg
Target Poly(ADP-ribose) Polymerase Inhibitors
Molecular Formula C24H23FN4O3
Purity 0.98