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Nimesulide
Highly selective cyclooxygenase-2 inhibitor which induces apoptosis | CAS: 51803-78-2 | C13H12N2O5S | 308.308 g/mol
Supplier: Thermo Scientific Chemicals J6369914
Description
Nimesulide are used for the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea, . Nimesulide was as effective as paracetamol in reducing fever, local pain, and general discomfort. It was effective in reducing pain associated with osteoarthritis, cancer, thrombophlebitis, oral surgery in adults, otorhinolaryngological diseases and traumatic injury. Nimesulide is demonstrated to suppress azoxymethane-induced carcinogenesis.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
SolubilitySoluble in water (<50 µg/ml), 1:10 DMSO:PBS (pH 7.2) (<200 µg/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.
Greener Choice Claims
- Environmental benefits include:
- Recyclable
- Recycled Content
- Renewable Materials
Specifications
| Nimesulide | |
| 145°C to 147°C | |
| C13H12N2O5S | |
| 25 g | |
| 14,6548 | |
| Soluble in water (<50 μg/ml),1:10 DMSO:PBS (pH 7.2) (<200 μg/ml),ethanol (1mg/ml),DMSO (15mg/ml),DMF (15mg/ml),chloroform,dichloromethane,acetone (freely soluble),and 1N NaOH. | |
| CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=CC=C2 | |
| 308.308 | |
| CHEBI:44445 | |
| Needle-like Crystals |
| 51803-78-2 | |
| Yellow | |
| MFCD00079470 | |
| UN2811 | |
| nimesulide, mesulid, n-4-nitro-2-phenoxyphenyl methanesulfonamide, flogovital, sulidene, nimed, 4-nitro-2-phenoxymethanesulfonanilide, nisulid, nimesulidum inn-latin, nimesulida inn-spanish | |
| HYWYRSMBCFDLJT-UHFFFAOYSA-N | |
| N-(4-nitro-2-phenoxyphenyl)methanesulfonamide | |
| 4495 | |
| 308.31 |
Chemical Identifiers
| 51803-78-2 | |
| 308.308 | |
| HYWYRSMBCFDLJT-UHFFFAOYSA-N | |
| 4495 | |
| N-(4-nitro-2-phenoxyphenyl)methanesulfonamide |
| C13H12N2O5S | |
| MFCD00079470 | |
| nimesulide, mesulid, n-4-nitro-2-phenoxyphenyl methanesulfonamide, flogovital, sulidene, nimed, 4-nitro-2-phenoxymethanesulfonanilide, nisulid, nimesulidum inn-latin, nimesulida inn-spanish | |
| CHEBI:44445 | |
| CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=CC=C2 |
Safety and Handling
GHS H Statement
H301
Toxic if swallowed.
P264b-P270-P301+P310-P330-P501c
H301
DOTInformation : Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber : 257-431-4
RTECSNumber : PB0970000
TSCA : No
Recommended Storage : Store at -20°C
RUO – Research Use Only