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Invitrogen™ LC3B Antibody Kit for Autophagy

Catalog No. L10382
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L10382 1 kit
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Catalog No. L10382 Supplier Invitrogen™ Supplier No. L10382
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Description

Includes

Kit includes includes a rabbit polyclonal antibody against LC3B and chloroquine diphosphate.

Use in fluorescence microscopy and high content imaging

The LC3 Antibody Kit for Autophagy includes a rabbit polyclonal antibody against LC3B that has been validated for use in fluorescence microscopy and high content imaging and analysis. Chloroquine diphosphate is also included - following treatment with this compound, normal autophagic flux is disrupted and autophagosomes accumulate as a result of the disruption in normal autophagic flux.

Apoptosis, Autophagy, Cell Analysis, Cell Metabolism, Cell Viability and Cytotoxicity, Cell Viability, Proliferation and Function, Endocytosis, Exocytosis and Phagocytosis

Order Info

Shipping Condition: Dry ice

Specifications

Content And Storage Kit includes includes a rabbit polyclonal antibody against LC3B and chloroquine diphosphate.
  • Store at ≤ -20°C
    		•
    Detection Method Fluorescence
    For Use With (Equipment) Confocal Microscope, Fluorescence Microscope, High Content Analysis Instrument
    Product Type Dye
    Dye Type Unlabeled
    Format 96-well plate, Slide(s)
    Quantity 1 kit
    Shipping Condition Dry Ice

    Frequently Asked Questions (FAQs)

    How does the LC3B Antibody Kit for Autophagy work?

    The LC3B protein plays a critical role in autophagy. This protein resides in the cytosol, but following cleavage and lipidation with phosphatidylethanolamine, LC3 associates with the phagophore. This localization can be used as a general marker for autophagic membranes. The LC3B Antibody Kit for Autophagy includes a rabbit polyclonal antibody against LC3B that has been validated for use in fluorescence microscopy and high content imaging and analysis. The kit also includes chloroquine diphosphate for artificially generating autophagosomes. Following chloroquine diphosphate treatment, lysosomal pH increases and the normal autophagic flux is disrupted, resulting in autophagosome accumulation.

    For Research Use Only. Not for use in diagnostic procedures.