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Tocris Bioscience™ Mdivi 1

Catalog No. 398250
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10 mg
50 mg
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Catalog No. Quantity
398250 50 mg
398210 10 mg
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Catalog No. 398250 Supplier Tocris Bioscience™ Supplier No. 3982/50
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Description

Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis

Mdivi 1 is a selective inhibitor of dynamin GTPase (IC50 = 1 - 10 μM); attenuates Dnm1- and Drp1-mediated mitochondrial division. Mdivi 1 inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis. In cancer cell lines, Mdivi 1 reduces cell proliferation; in an animal model of ischemic retina Mdivi 1 treatment blocks apoptosis. In a cell model, Mdivi 1 protects against mutant huntington-induced damage and mitochondrial dysfunction. Mdivi 1 also inhibits autophagy and protects neurons from excitotoxicity.

Chemical Identifiers

CAS 338967-87-6
Molecular Formula C15H10Cl2N2O2S

Specifications

Quantity 50 mg
Formula Weight 353.22
Purity >98%
Molecular Weight (g/mol) 353.217
Chemical Name or Material Dynamin Inhibitors

Safety and Handling

Recommended Storage Store at -20°C