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  7. Thermo Scientific Chemicals Lovastatin, 98%

Thermo Scientific Chemicals Lovastatin, 98%

Catalog No. p-7077757
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AC458830050 5 g
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Catalog No. AC458830050 Supplier Thermo Scientific Chemicals Supplier No. 458830050
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Description

Lovastatin, CAS # 75330-75-5, is a cholesterol lowering compound and inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. | CAS: 75330-75-5 | C24H36O5 | 404.55 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Applications

• It blocks product ion of mevalonate, a critical compound in the production of cholesterol and isoprenoids

• It can increase cellular resistance to anticancer agents such as doxorubicin • It can induce apoptosis in myeloma cells

• It can cause cell cycle arrest in G1 and G2/M phase

• It also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF

Chemical Identifiers

CAS 75330-75-5
Molecular Formula C24H36O5
Molecular Weight (g/mol) 404.55
MDL Number MFCD00072164
InChI Key PCZOHLXUXFIOCF-BXMDZJJMSA-N
Synonym lovastatin, mevinolin, mevacor, monacolin k, lovalip, altoprev, lovalord, mevinacor, nergadan, 6alpha-methylcompactin
PubChem CID 53232
ChEBI CHEBI:40303
IUPAC Name [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
SMILES CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12

Specifications

Melting Point 175.0°C
Infrared Spectrum Authentic
Assay Percent Range 97.5% min. (HPLC)
Quantity 5 g
Solubility Information Solubility in water: insoluble. Other solubilities: less soluble in ethanol, soluble in chloroform and acetone
Formula Weight 404.54
Percent Purity 98%
Chemical Name or Material Lovastatin

Safety and Handling

Hazard Category GHS Signal Word: Warning
Hazard Statement GHS H Statement
May cause an allergic skin reaction.
Suspected of causing cancer.
Suspected of damaging the unborn child.
Precautionary Statement GHS P Statement
Wear protective gloves/protective clothing.
IF ON SKIN: Wash with plenty of soap and water.
Obtain special instructions before use.
IF exposed or concerned: Get medical advice/attention.

RUO – Research Use Only