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  6. HER-2/c-erbB-2/neu Ab-4 Mouse Monoclonal Antibody, Epredia™

HER-2/c-erbB-2/neu Ab-4 Mouse Monoclonal Antibody, Epredia™

Numéro de catalogue. MS301P1
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Quantité:
500 μL
1 mL
Conjugué:
Biotin
Unconjugated
Concentration:
200μg/mL
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Product selection table with 4 available options. Use arrow keys to navigate and Enter or Space to select.
Numéro de catalogue. Quantité Conjugué Concentration
MS301P1 500 μL Unconjugated 200μg/mL
MS301B1 500 μL Biotin 200μg/mL
MS301B 1 mL Biotin 200μg/mL
MS301P 1 mL Unconjugated 200μg/mL
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Numéro de catalogue. MS301P1 Fournisseur Thermo Fisher Scientific Code fournisseur MS301P1

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Description

Provide accurate, reproducible results with the Epredia™ HER-2/c-erbB-2/neu Ab-4, Mouse Monoclonal Antibody.

c-erbB-2, second member (c-erbB-2/HER-2/neu) of the c-erbB family is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein

Host Species: Mouse

Clone: N12

Isotype: IgG1

Species Reactivity: Human. Does not react with mouse and rat. Others not tested.

Epitope: Extracellular domain

Immunogen: Intact SKBR-3 breast cancer cells

Molecular Weight: 185 kDa

Positive Control: SKBR-3 cells, or Breast CA

Cellular Localization: Membrane

Recommended for:

  • Immunofluorescence
  • Immunoprecipitation (Not suitable)
  • Inhibits Tumor Growth (∽90%)
  • Inhibits Cell Proliferation
  • Effect on HER-2 Internalization (Moderate)
  • Electron Microscopy

Note:

USA: RUO; Int'l: RUO

Spécifications

Antigène HER-2/c-erbB-2/neu Ab-4
Applications Immunofluorescence, Immunohistochemistry (Frozen)
Classification Monoclonal
Clone N12
Concentration 200μg/mL
Conjugué Unconjugated
Espèces hôtes Mouse
Immunogène Intact SKBR-3 breast cancer cells
Quantité 500 μL
Statut réglementaire RUO
Disciplines de recherche EGFR Family
Primaire ou secondaire Primary
Espèces cibles Human
Forme Concentrated
Isotype IgG1
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