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  6. Invitrogen™ ITCH Recombinant Rabbit Monoclonal Antibody (23GB6255)

Invitrogen™ ITCH Recombinant Rabbit Monoclonal Antibody (23GB6255)

Numéro de catalogue. MA553007
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20 μL
100 μL
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Numéro de catalogue. Quantity
MA553007 20 μL
MA553006 100 μL
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Numéro de catalogue. MA553007 Fournisseur Invitrogen™ Code fournisseur MA553007
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Description

Rabbit Recombinant Monoclonal Antibody

ITCH Recombinant Monoclonal Antibody for Flow, ICC/IF, Western Blot

Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.

Spécifications

Antigen ITCH
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 23GB6255
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ITCH
Gene Accession No. Q8C863, Q96J02
Gene Alias 6720481N21Rik; 8030492O04Rik; A130065M08; ADMFD; AIF4; AIP4; atrophin-1 interacting protein 4; Atrophin-1-interacting protein 4; C230047C07Rik; dJ468O1.1; E3 ubiquitin-protein ligase Itchy; E3 ubiquitin-protein ligase Itchy homolog; HECT-type E3 ubiquitin transferase Itchy homolog; ITCH; itch E3 ubiquitin ligase; itchy E3 ubiquitin protein ligase; itchy E3 ubiquitin protein ligase homolog; itchy, E3 ubiquitin protein ligase; NAPP1; NFE2-associated polypeptide 1
Gene Symbols ITCH
Host Species Rabbit
Immunogen A synthesized peptide derived from human ITCH (10-66AA).
Purification Method Affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16396, 311567, 83737
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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