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  6. Invitrogen™ Integrin beta 5 Monoclonal Antibody (KN52), FITC, eBioscience™, Invitrogen™

Invitrogen™ Integrin beta 5 Monoclonal Antibody (KN52), FITC, eBioscience™, Invitrogen™

Numéro de catalogue. 509611
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509611 25 Tests
509612 100 Tests
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Numéro de catalogue. 509611 Fournisseur Invitrogen™ Code fournisseur 11049741

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Description

Mouse Monoclonal Antibody

Description: The KN52 antibody reacts with human integrin beta 5, an approximately 100,000 Mr (reduced) and 95,000 Mr (nonreduced) a member of the integrin family. Only a single alpha chain, the alpha v subunit, associates with the integrin beta 5 to form the vitronectin receptor complex. Integrin alpha v/beta 5 complex also binds to the basic domain of Tat (he sequence RKKRRQRRR). The integrin beta 5 is found on carcinoma cell lines, hepatoma and fibroblast cell lines, and is absent from lymphoblastoid cells and platelets. The KN52 monoclonal antibody has been shown to inhibit migration. Applications Reported: This KN52 antibody has been reported for use in flow cytometric analysis. Applications Tested: This KN52 antibody has been pre-titrated and tested by flow cytometric analysis of Chinese Hamster Ovary (CHO), A549 and normal human peripheral blood cells. This can be used at 5 μL (0.125 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered.

Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around 22 different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell-surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in-groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N-terminal extracellular domain that binds the ECM ligand and a small C-terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function.

Spécifications

Antigène Integrin beta 5
Applications Flow Cytometry
Classification Monoclonal
Clone KN52
Concentration 5 μL/Test
Conjugué FITC
Formule PBS with BSA and 0.09% sodium azide; pH 7.2
Gène Itgb5
Numéro d’acquisition du gène O70309, P18084
Alias du gène [b]5; [b]-5; [b]5A; [b]5B; AA475909; AI874634; beta5; beta-5; CD61; ESTM23; FLJ26658; GP3A; GPIIIa; I79_000655; integrin beta 5; integrin beta-5; integrin subunit beta 5; integrin, beta 5; ITGB5; RGD1563276; testis secretory sperm-binding protein Li 217p
Symboles de gène Itgb5
Espèces hôtes Mouse
Méthode de purification Affinity chromatography
Quantité 25 Tests
Statut réglementaire RUO
Primaire ou secondaire Primary
ID du gène (Entrez) 100765378, 16419, 3693
Espèces cibles Hamster, Human, Mouse
Contenu et stockage 4°C, store in dark, DO NOT FREEZE!
Type de produit Antibody
Forme Liquid
Isotype IgG1 κ
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For Research Use Only.