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Invitrogen™ Human LXR alpha (aa 318-329) Synthetic Peptide

Catalog No. PEP114
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50 μg
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Catalog No. Quantity
PEP114 50 μg
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Catalog No. PEP114 Supplier Invitrogen™ Supplier No. PEP114

Description

Synthetic Peptide

PEP-114 is a 12 amino acid synthetic peptide whose sequence corresponds to residues 318-329 of human LXR alpha with an amino-terminal cysteine added for carrier protein conjugation. The sequence of this peptide is (amino to carboxy terminus): C-D318-F-S-Y-N-R-E-D-F-A-K-A (329). This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human LXR alpha, catalog # PA1-330. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions. Reconstitute with 0.1 mL of distilled water.

NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.

Specifications

Gene ID (Entrez) 10062
Species Human
Purification Method purified
Accession Number Q13133
Common Name LXR alpha
Concentration 0.5 mg/mL
Content And Storage -20°C. Avoid freeze-thaw cycles.
Description Synthetic Peptide
Format Lyophilized
Formulation Peptide with no preservative
For Use With (Application) Control
Gene Alias AU018371; liver X nuclear receptor alpha variant 1; liver X receptor alpha; LXR; LXR alpha; Lxra; LXR-a; LXRalpha; LXRb; NER; NERI; NR1H2; Nr1h3; nuclear orphan receptor LXR-alpha; nuclear oxysterol receptor LxR-alpha; nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; oxysterols receptor LXR-alpha; RLD1; RLD-1; ubiquitously-expressed nuclear receptor 1; Unr1
Gene Symbol NR1H3
Lyophilized Yes
Preservative No preservative
Product Type Peptide
Quantity 50 μg
Regulatory Status RUO
Sequence C-D318-F-S-Y-N-R-E-D-F-A-K-A(329)
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