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Invitrogen™ Human ITGA4 Synthetic Peptide

Numéro de catalogue. PEP0719
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50 μg
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Numéro de catalogue. Quantity
PEP0719 50 μg
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Numéro de catalogue. PEP0719 Fournisseur Invitrogen™ Code fournisseur PEP0719

Description

Synthetic Peptide

This peptide corresponds to 16 amino acids near the center of human integrin alpha 4# PEP-0719 can be used as a blocking peptide with polyclonal antibody PA5-20599.

The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.

Spécifications

Species Human
Purification Method purified
Accession Number P13612
Common Name CD49d (Integrin alpha 4)
Concentration 200 μg/mL
Format Liquid
Formulation PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
Gene Alias 269C wild type; alpha 4 subunit of VLA-4 receptor; antigen CD49D, alpha-4 subunit of VLA-4 receptor; CD49 antigen-like family member D; CD49d; IA4; integrin alpha 4; integrin alpha-4; integrin alpha4B; Integrin alpha-IV; integrin subunit alpha 4; integrin, alpha 4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); Itga4; Itga4B; ITGA-IV; LPAM subunit alpha; lymphocyte Peyer patch adhesion molecules subunit alpha; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 receptor, alpha 4 subunit; VLA-4 subunit alpha
Gene Symbol ITGA4
Lyophilized No
Preservative Sodium azide
Product Type Peptide
Quantity 50 μg
Regulatory Status RUO
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