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Invitrogen™ Human HDAC4 (aa 1071-1084) Synthetic Peptide

Catalog No. PEP141
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50 μg
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Catalog No. Quantity
PEP141 50 μg
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Catalog No. PEP141 Supplier Invitrogen™ Supplier No. PEP141

Description

Synthetic Peptide

PEP-141 is a 14 amino acid synthetic peptide whose sequences are derived from amino acids 1071-1084 of human HDAC4. The sequence of this peptide is (amino to carboxy terminus): K (1071)-R-P-D-E-E-P-M-E-E-E-P-P-L (1084) PEP-141 may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human HDAC4, catalog # PA1-863, Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions. Reconstitute with 0.1 mL of distilled water.

Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC4 is also involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. It is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Mutations to the HDAC4 gene have been found in Brachydactyly-mental retardation syndrome (BDMR).

Specifications

Gene ID (Entrez) 9759
Species Human
Purification Method purified
Accession Number P56524
Common Name HDAC4
Concentration 0.5 mg/mL
Content And Storage -20°C. Avoid freeze-thaw cycles.
Description Synthetic Peptide
Format Lyophilized
Formulation Peptide with no preservative
For Use With (Application) Control
Gene Alias 4932408F19Rik; AHO3; AI047285; BDMR; DKFZp779K1053; HA6116; HD4; HD7; HD7b; HD9; HDAC; HDAC4; HDAC-4; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDACA; HDAC-A; HDRP; Histone deacetylase 4; histone deacetylase A; KIAA0288; KIAA0744; MITR
Gene Symbol HDAC4
Lyophilized Yes
Preservative No preservative
Product Type Peptide
Quantity 50 μg
Regulatory Status RUO
Sequence K(1071)-R-P-D-E-E-P-M-E-E-E-P-P-L(1084)
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