missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. PHC1564

Gibco™ Human 4-1BB Ligand (TNFSF9) Recombinant Protein

Numéro de catalogue. phc1564
Encompass
Change view
Click to view available options
Quantity:
20 μg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Numéro de catalogue. Quantity
PHC1564 20 μg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Numéro de catalogue. PHC1564 Fournisseur Gibco™ Code fournisseur PHC1564
Il en reste null

Description

Recombinant Protein

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile, distilled water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2°C to 8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein, such as 0.1% BSA and store in working aliquots at -80°C to -20°C. Storage: The lyophilized protein is stable at room temperature for 1 month, but should be kept at -20°C for long term storage. Working aliquots stored with a carrier protein are stable for at least 3 months at -80°C to -20°C. Avoid repeated freeze/thaw cycles.

CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.

Spécifications

Accession Number P41273
For Use With (Application) Bioactivity
Formulation 5mM tris with 75mM NaCl and no preservative; pH 8
Gene ID (Entrez) 8744
Molecular Weight (g/mol) 19.5 kDa
Name Human 4-1BB Ligand (TNFSF9)
pH Range 8
Purification Method Purified
Quantity 20 μg
Storage Requirements -20°C
Regulatory Status RUO
Endotoxin Concentration <0.1 ng/μg
Gene Alias 4 1 BB Ligand; 4 1 BBL; 41BB Ligand; 4-1BB ligand; 41BBL; 4-1BBL; 4-1BB-L; AI848817; CD 137 Ligand; CD 137L; CD137 Ligand; CD137L; Cd157l; CDw137L; costimulatory molecule; homolog of mouse 4-1BB-L; Ly63l; receptor 4-1BB ligand; TNFRSF9; Tnfsf9; TNLG5A; tumor necrosis factor (ligand) superfamily member 9; tumor necrosis factor (ligand) superfamily, member 9; tumor necrosis factor ligand 5A; tumor necrosis factor ligand superfamily member 9; tumor necrosis factor superfamily member 9
Common Name 4-1BBL (CD137L)
Gene Symbol TNFSF9
Biological Activity ED50 = 5 - 10 ng/mL; determined by the dose-dependent stimulation of IL-8 production by human PBMCs.
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Sequence Human 4-1BB Ligand recombinant protein contains 185 amino acids
Content And Storage -20°C
Activity ED50 = 5 - 10 ng/mL; determined by the dose-dependent stimulation of IL-8 production by human PBMCs.
Endotoxin Level <0.1 ng/μg
Shipping Condition Approved for shipment on Wet or Dry Ice
Expression System E. coli
Protein Family Cytokines & Receptors
Protein Form Recombinant, Ligand
Form Lyophilized
Protein Subtype Other Proteins
Research Category Immunology, Cardiovascular Research, Signal Transduction, Apoptosis
Product Line Gibco
Purity or Quality Grade ≥98% by SDS-PAGE and HPLC
Afficher plus de résultats Afficher moins de résultats