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Invitrogen™ HSP90 alpha Polyclonal Antibody
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Numéro de catalogue. PA3013
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Quantité:
100 μg
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Numéro de catalogue. Quantité
PA3013 100 μg
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Numéro de catalogue. PA3013 Fournisseur Invitrogen™ Code fournisseur PA3013

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Description

Rabbit Polyclonal Antibody

PA3-013 detects heat shock protein 90 (HSP90) from human, monkey, mouse, sheep (adrenal) and rat tissues and cells. This antibody does not detect HSP84. PA3-013 has been successfully used in Western blot, immunofluorescence, immunohistochemistry (paraffin) and immunoprecipitation procedures. By Western blot, this antibody detects an ~86 kDa protein representing HSP86 from HeLa cell lysate. Immunofluorescence staining of HSP86 in HeLa cells with PA3-013 yields a pattern consistent with cytoplasmic staining. Immunoprecipitation experiments with this antibody suggest that HSP86 exists primarily as homodimers in HeLa cells. Furthermore, the antibody is capable of precipitating HSP86 that is complexed with other proteins such as the aryl hydrocarbon (Ah) receptor. The PA3-013 immunogen is a synthetic peptide corresponding to residues P(2) E E T Q T Q D Q P M(12) of mouse HSP86. The N-terminal regions of HSP84 and HSP86 show the largest difference in amino acid sequence.

Heat shock proteins (HSP) are proteins that are expressed in response to various biological stress, including heat. HSP90 is a 90 kDa protein that is induced under stress conditions, but is also one of the most abundant cellular proteins found under non-stress conditions. HSP90 has been found to be associated with a number of other intracellular proteins, including steroid receptors, actin, tubulin, and some kinases. It has been suggested that HSP90 is necessary to maintain structural integrity of at least some steroid receptors to allow for ligand binding during receptor activation.

Spécifications

Antigène HSP90 alpha
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugué Unconjugated
Formule PBS with 1mg/mL BSA and 0.05% sodium azide
Gène Hsp90aa1
Numéro d’acquisition du gène P07900, P07901, P82995
Alias du gène 86kDa; 89kDa; 90-kDa heat shock protein; 90-kDa heat shock protein alpha; akineto; AL024080; AL024147; EL52; epididymis luminal secretory protein 52; epididymis secretory sperm binding protein Li 65p; fb17b01; heat shock 86 kDa; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, alpha; heat shock protein 86; heat shock protein 90; heat shock protein 90 alpha family class A member 1; heat shock protein 90, alpha (cytosolic), class A member 1; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1; heat shock protein 90-alpha 1; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha family class A member 1; heat shock protein alpha; Heat shock protein HSP 90-alpha; Heat shock protein HSP 90-alpha 1; heat shock protein HSP90 alpha; heat shock protein hsp90alpha; heat shock protein, 1; heat shock protein, 86 kDa 1; heat shock protein, 89 kDa; Heat shock protein90; HEL-S-65p; HSP; HSP 86; HSP 90 alpha; hsp4; HSP86; Hsp86-1; Hsp89; HSP89A; HSP90; hsp90a; hsp90a protein; hsp90a.1; hsp90aa1; hsp90aa1.1; hsp90alpha; HSP90N; HSPC1; Hspca; HSPCA protein; HSPCAL1; HSPCAL4; HSPN; hypothetical protein; LAP2; LAP-2; Lipopolysaccharide-associated protein 2; LPS-associated protein 2; renal carcinoma antigen NY-REN-38; slo; sloth; TSTA; Tumor-specific transplantation 86 kDa antigen; wu:fb17b01; zgc:86652
Symboles de gène Hsp90aa1
Espèces hôtes Rabbit
Immunogène Synthetic peptide corresponding to residues P(2) E E T Q T Q D Q P M(12) of mouse HSP86.
Méthode de purification Affinity chromatography
Quantité 100 μg
Statut réglementaire RUO
Primaire ou secondaire Primary
ID du gène (Entrez) 100127209, 15519, 299331, 3320
Espèces cibles Human, Mouse, Rat, Monkey, Sheep
Contenu et stockage -20°C, Avoid Freeze/Thaw Cycles
Type de produit Antibody
Forme Liquid
Isotype IgG
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