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  7. Histamine dihydrochloride, 98+%

Histamine dihydrochloride, 98+%

Catalog No. AAL0919806
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Catalog No. AAL0919806 Supplier Thermo Scientific Chemicals Supplier No. L0919806
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Description

CAS: 56-92-8 | C5H11Cl2N3 | 184.06 g/mol

Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor. It is a potent vasodilator and endogenous histamine receptor agonist.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor. It is a potent vasodilator and endogenous histamine receptor agonist.

Solubility
Very soluble in water and methanol. Soluble in ethanol.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents. Store away from oxidizing agents. Store at 4°C.

Chemical Identifiers

CAS 56-92-8
Molecular Formula C5H11Cl2N3
Molecular Weight (g/mol) 184.06
MDL Number MFCD00012703
InChI Key PPZMYIBUHIPZOS-UHFFFAOYSA-N
Synonym histamine dihydrochloride, histamine 2hcl, 2-1h-imidazol-4-yl ethanamine dihydrochloride, 1h-imidazole-4-ethanamine dihydrochloride, 1h-imidazole-4-ethanamine, dihydrochloride, peremin, ceplene, 2-1h-imidazol-4-yl ethylamine dihydrochloride, 2-4-imidazolyl ethylamine dihydrochloride, histaminedium dichloride
PubChem CID 5818
IUPAC Name 2-(1H-imidazol-5-yl)ethanamine;dihydrochloride
SMILES [H+].[H+].[Cl-].[Cl-].NCCC1=CN=CN1

Specifications

Melting Point 245°C to 249°C
Quantity 5 g
Beilstein 3624116
Merck Index 14,4719
Solubility Information Very soluble in water and methanol. Soluble in ethanol.
Formula Weight 184.07
Percent Purity ≥98%
Chemical Name or Material Histamine dihydrochloride

Safety and Handling

Hazard Category H315-H317-H319-H334-H335
Hazard Statement GHS H Statement
H334-H335-H315-H319-H317
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
May cause respiratory irritation.
Causes skin irritation.
Causes serious eye irritation.
May cause an allergic skin reaction.
Precautionary Statement P261-P264b-P271-P272-P280-P285-P302+P352-P304+P340-P305+P351+P338-P333+P313-P342+P311-P362-P501c
EINECSNumber 200-298-4
RTECSNumber MS1575000
TSCA Yes
Recommended Storage Ambient temperatures

RUO – Research Use Only