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Gibco™ HepaRG™ Cells, Cryopreserved

Catalog No. HPRGC10
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HPRGC10 1 vial
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Description

The HepaRG™ Cells, Cryopreserved cell line is an immortalized hepatic cell line that retains many characteristics of primary human hepatocytes.

The HepaRG™ cell line is an immortalized hepatic cell line that retains many characteristics of primary human hepatocytes. HepaRG™ cells are terminally differentiated and provided in a convenient cryopreserved format. For scientists who need reproducible metabolism data, HepaRG™ cells are an in vitro tool that provides reproducible results in a metabolically complete and scalable system.

  • Obtain biologically relevant results from a metabolically complete system
  • Assess the drug-drug interaction potential of your compound
  • Experience reproducible results from a single population of cells

Biologically Relevant

HepaRG™ cells exhibit many characteristics of primary human hepatocytes including morphology, expression of key metabolic enzymes, expression of nuclear receptors, and drug transporters. Unlike HepG2 and Fa2N-4 cells, HepaRG™ cells have high P450 activity and complete expression of all nuclear receptors.

Predict Metabolism-based Drug-drug Interaction

HepaRG™ cells respond to prototypical P450 inducers and inhibitors to the same extent as primary hepatocytes, allowing HepaRG™ cells to be used to evaluate potential drug-drug interactions.

Infinitely Reproducible

HepaRG™ cells exhibit many characteristics of primary human hepatocytes and are essentially a single donor. These features allow users to obtain physiological relevant results for metabolism-based drug-drug interactions without the concern of donor variability and limited lot sizes that come with relying on donor tissue. (Note: The cells we provide are terminally differentiated).

HepaRG™ is a trademark of BioPredic International.

Specifications

Content And Storage 1 vial, store in cryostorage dewar or -135°C freezer
Age Adult
Cell Line HepaRG
Cell Type Hepatocytes
Culture Type Hepatocyte Cell Culture
Form Cryopreserved
Gender Female
Species Human
Tissue Liver
Donor Source Single Donor
No. of Cells 10 x 106
Product Type Hepatocytes
Quantity 1 vial
Shipping Condition Dry Ice
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For Research Use Only. Not for use in diagnostic procedures.