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Invitrogen™ GITR (TNFRSF18) Recombinant Rat Monoclonal Antibody (YGITR765)
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Numéro de catalogue. MA551852
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Quantity:
200 μg
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Numéro de catalogue. Quantity
MA551852 200 μg
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Numéro de catalogue. MA551852 Fournisseur Invitrogen™ Code fournisseur MA551852
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Description

Rat Recombinant Monoclonal Antibody

This antibody binds murine GITR.

Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. It is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Spécifications

Antigen GITR (TNFRSF18)
Applications Flow Cytometry, Inhibition Assays
Classification Recombinant Monoclonal
Clone YGITR765
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene Tnfrsf18
Gene Accession No. O35714
Gene Alias Activation-inducible TNFR family receptor; AITR; CD357; GITR; GITR-D; glucocorticoid-induced TNFR-related protein; PRO364; TNF receptor superfamily activation-inducible protein; TNF receptor superfamily member 18; TNFRSF18; Tumor necrosis factor receptor superfamily member 18; tumor necrosis factor receptor superfamily, member 18; UNQ319; UNQ319/PRO364
Gene Symbols Tnfrsf18
Host Species Rat
Immunogen nB2/6TG cells transfected with mouse GITR injected into DA rats.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21936
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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