Genlantis™ PrimaPure™ Human Aortic Smooth Muscle Cells (HAOSMC) and Kits

Human Aortic Smooth Muscle Cells (HAOSMC ) are derived from tunica intima and tunica media of normal human, fibrous plaque-free aorta. They are cryopreserved at second passage and can be cultured and propagated at least 16 population doublings. Arterial smooth muscle cells are capable of synthesizing collagen, elastin, myosin and glycosaminoglycan¹,². Increased production of connective tissue components, hyperplasia and hypertrophy of intimal smooth muscle cells are found to gradually occlude the vessel lumen in atherosclerosis¹,². HAOSMC respond to various factors by proliferating or differentiating³,⁴. They are a well established cell system for the study of human vascular disorders such as atherosclerosis⁵,⁶ and stroke.

• Each lot functionally characterized
• Lots from single donors to allow variability comparisons
• Each lot tested negative for HIV, Hepatitis B & C, mycoplasma, bacteria, yeast, and fungi
• 16 population doublings guaranteed with Genlantis media and reagents

REFERENCES:
1. Abraham, P.A. et al, Biochem. Biophys. Res. Comm. 58:597 (1974).
2. Ross, R., New Engl. J. Med. 314(8):488 (1986).
3. Fager, G. et al, In Vitro Cell. Biol. 25(6):511 (1989).
4. Hoshi, H. et al, In Vitro Cell. Biol. 24(4):309 (1988).
5. Orekhov, A.N. et al, Lab. Invest. 48:749 (1983).
6. Jonasson, L. et al, Arteriosclerosis 6(2):131 (1986).