missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. AAJ64753MA

EX 527

Catalog No. AAJ64753MA
Change view
missing translation for 'orderingAttributeHoverText'
Quantity:
10 mg
Catalog No. Quantity
AAJ64753MA 10 mg
1 options

Catalog No. AAJ64753MA

Supplier: Thermo Scientific Chemicals J64753MA

Only null left

Description

CAS: 49843-98-3 | C13H13ClN2O | 248.71 g/mol

EX-527 is a potent and selective sirtuin 1 (SIRT1) inhibitor (IC50 38 nM) identified from a high throughput screen. EX-527 is more selective (200-500-fold) for SIRT1 than for SIRT2 or SIRT3 and has been shown to be a potent SIRT6 inhibitor using H3K56 deacetylation site based substrate. EX-527 does not inhibit class I/II HDAC activity at concentrations up to 100uM. Enhances p53 acetylation in response to DNA damaging agents. EX-527 is racemic; the active isomer (EX-243) gives similar results and potency whereas the other isomer (designated EX-242) is inactive.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
EX-527 is a potent and selective sirtuin 1 (SIRT1) inhibitor (IC50 38 nM) identified from a high throughput screen. EX-527 is more selective (200-500-fold) for SIRT1 than for SIRT2 or SIRT3 and has been shown to be a potent SIRT6 in

Chemical Identifiers

CAS 49843-98-3
Molecular Formula C13H13ClN2O
Molecular Weight (g/mol) 248.71
MDL Number MFCD03009471
InChI Key FUZYTVDVLBBXDL-UHFFFAOYSA-N
Synonym selisistat, sirt1 inhibitor iii, 1h-carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro, 6-chloro-2,3,4,9-tetrahydro-1h-carbazole-1-carboxamide, racemic, selisistat inn, 6-chloro-1,2,3,4,9-pentahydro-4ah-carbazolecarboxamide, ex-527 selisistat, ex 527 selisistat, d0e3lp, cambridge id 6859180
PubChem CID 5113032
IUPAC Name 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
SMILES C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N

Specifications

Color White
Quantity 10 mg
Solubility Information Soluble in dimethyl sulfoxide,ethanol and dimethyl formamide.
Formula Weight 248.71
Physical Form Powder
Chemical Name or Material EX 527

Safety and Handling

Hazard Category H302-H319
Hazard Statement GHS H Statement
H302-H319
Harmful if swallowed.
Causes serious eye irritation.
Precautionary Statement P264b-P270-P280i-P301+P312-P305+P351+P338-P330-P501c
TSCA No
Recommended Storage Keep cold

RUO – Research Use Only