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Invitrogen™ Human DNA-PK Native Protein

Numéro de catalogue. PV5865
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Numéro de catalogue. Quantity
PV5865 1 mg
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Numéro de catalogue. PV5865 Fournisseur Invitrogen™ Code fournisseur PV5865

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Description

Native Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Native human protein purified from MOLT-4 cells. No special measures were taken to activate this kinase. Protein Form: Full Length

DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. DNA-PK is an atypical kinase, closely related to the PI3 kinases, and is often potently inhibited by small molecules designed to target PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for DNA-PK.

Spécifications

Accession Number P78527
Concentration Conc. Not Determined
For Use With (Application) Kinase Assay
Formulation 25 mM HEPES with 0.2 mM EDTA, 10% glycerol, 10 mM MgCl2, 1 mM DTT, 50 mM KCl and no preservative; pH 7.5
Gene ID (Entrez) 5591
Molecular Weight (g/mol) 600 kDa
Name Human DNA-Pk.
Quantity 1 mg
Regulatory Status RUO - research use only
Gene Alias AI326420; AU019811; DNA-dependent protein kinase catalytic subunit; DNAPDcs; DNAPK; DNA-Pk. catalytic subunit; DNA-PKcs; DNPK1; DOXNPH; doxorubicin nephropathy; dxnph; hyper-radiosensitivity of murine scid mutation, complementing 1; HYRC; HYRC1; I79_017613; IMD26; p350; p460; Prkdc; protein kinase, DNA activated, catalytic polypeptide; protein kinase, DNA-activated, catalytic polypeptide; scid; severe combined immunodeficiency; slip; Xrcc7
Common Name DNA-Pk.
KinaseFamily PIKK Kinase Family
Conjugate Unconjugated
Species Human
Sequence Full length
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Form Liquid
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