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  6. Thermo Scientific Chemicals DL-1,4-Dithiothreitol, 99%, for biochemistry

Thermo Scientific Chemicals DL-1,4-Dithiothreitol, 99%, for biochemistry

Numéro de catalogue. AC165680250
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AC165680250 25 g
AC165680010 1 g
AC165680050 5 g
AC165681000 100 g
AC165685000 500 g
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Numéro de catalogue. AC165680250 Fournisseur Thermo Scientific Chemicals Code fournisseur 165680250
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Description

1,4-Dithiothreitol, CAS # 3483-12-3, is a reducing agent commonly used to reduce disulphide bonds in protein studies, such as western blot SDS-page electrophoresis. | CAS: 3483-12-03 | C4H10O2S2 | 154.25 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

  • 1,4-Dithiothreitol (DTT or Cleland's reagent) reduces disulfide bonds in proteins, leading to loss of native conformation
  • DTT is not stable in solution and should be prepared in small aliquots prior to use; the use of EDTA in the solution can increase the half-life of DTT
  • Typically used at a final concentration of 0.1M for protein stabilization; recommended to create a 1M stock

Applications

  • Protects thiol groups from oxidation and acts as a chemical chelator in solution; maintains proteins in the denatured state
  • Common applications include SDS-page electrophoresis and protein isolation

Identifiants chimiques

CAS 12-3-3483
MDL Number MFCD00004877
InChI Key VHJLVAABSRFDPM-IMJSIDKUSA-N
Synonym dithiothreitol, dl-1,4-dithiothreitol, dl-dithiothreitol, 1,4-dithio-dl-threitol, d-1,4-dithiothreitol, d-dtt, 2s,3s-1,4-dimercaptobutane-2,3-diol, threo-1,4-dimercapto-2,3-butanediol, 1,4-dithiothreitol, dtt
PubChem CID 446094
ChEBI CHEBI:42170
IUPAC Name (2S,3S)-1,4-bis(sulfanyl)butane-2,3-diol
SMILES C(C(C(CS)O)O)S

Spécifications

Absorbance (1 M soln. in water), (1 M soln. in water) at 0nm, 0.035 max. at 500nm
Melting Point 39°C to 44°C
Color White
Infrared Spectrum Authentic
Assay Percent Range 0.99
Molecular Formula C4H10O2S2
Linear Formula HSCH2CH(OH)CH(OH)CH2SH
Quantity 25 g
Beilstein 01, III, 2360
Merck Index 15, 3419
Transmittance 99% min. (c=5, 660nm, water) 1cm cell
Molecular Weight (g/mol) 154.24
Formula Weight 154.24
Percent Purity ≥98.5%
Grade Biochemical
Physical Form Powder
Chemical Name or Material DL-1, 4-Dithiothreitol
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Sécurité et manipulation

Hazard Category Serious eye damage/eye irritation (category 2), Acute toxicity (category 4), Specific target organ toxicity after single exposure (category 3), Skin corrosion/irritation (category 2)
Hazard Statement Causes serious eye irritation, Harmful if swallowed, May cause respiratory irritation, May form combustible dust concentrations in air, Causes skin irritation

RUO – Research Use Only