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  7. Diethyl (bromodifluoromethyl)phosphonate, 97%

Diethyl (bromodifluoromethyl)phosphonate, 97%

Catalog No. AAL1671503
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Catalog No. AAL1671503 Supplier Thermo Scientific Chemicals Supplier No. L1671503
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Description

CAS: 65094-22-6 | C5H10BrF2O3P | 267.01 g/mol

Diethyl (bromodifluoromethyl)phosphonate is used as a reactant for the preparation of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat3), synthesis of Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory difluoromethylphosphonic acid derivatives via multi step synthesis with Suzuki coupling and resolution as key steps and P-C bond cleavage on basic hydrolysis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Diethyl (bromodifluoromethyl)phosphonate is used as a reactant for the preparation of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat3), synthesis of Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory difluoromethylphosphonic acid derivatives via multi step synthesis with Suzuki coupling and resolution as key steps and P-C bond cleavage on basic hydrolysis.

Solubility
Not miscible or difficult to mix in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Incompatible with oxidizing agents.

Chemical Identifiers

CAS 65094-22-6
Molecular Formula C5H10BrF2O3P
Molecular Weight (g/mol) 267.01
MDL Number MFCD00069118
InChI Key QRADKVYIJIAENZ-UHFFFAOYSA-N
Synonym diethyl bromodifluoromethyl phosphonate, bromodifluoromethyl diethylphosphonate, diethyl bromodifluoromethanephosphonate, diethyl bromodifluoromethylphosphonate, bromodifluoromethyl phosphonic acid diethyl ester, 1-bromo difluoro methyl-ethoxyphosphoryl oxyethane, phosphonic acid, bromodifluoromethyl-, diethyl ester, pubchem24183, acmc-20ai7p
PubChem CID 144101
IUPAC Name 1-[[bromo(difluoro)methyl]-ethoxyphosphoryl]oxyethane
SMILES CCOP(=O)(OCC)C(F)(F)Br

Specifications

Density 1.503
Boiling Point 99°C to 102°C (16 mmHg)
Flash Point >110°C (230°F)
Refractive Index 1.416
Quantity 1 g
Beilstein 1944045
Solubility Information Not miscible or difficult to mix in water.
Formula Weight 267.01
Percent Purity 97%
Chemical Name or Material Diethyl (bromodifluoromethyl)phosphonate

Safety and Handling

Hazard Category H315-H319
Hazard Statement GHS H Statement
H315-H319
Causes skin irritation.
Causes serious eye irritation.
Precautionary Statement P264b-P280-P302+P352-P305+P351+P338-P332+P313-P362
TSCA No
Recommended Storage Ambient temperatures

RUO – Research Use Only