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DAPT

Catalog No. AAJ65864MA
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Quantity:
10 mg
Catalog No. Quantity
AAJ65864MA 10 mg
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Catalog No. AAJ65864MA

Supplier: Thermo Scientific Chemicals J65864MA

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Description

CAS: 208255-80-5 | C23H26F2N2O4 | 432.468 g/mol

DAPT is used in the study of β-amyloid formation. DAPT has been shown to inhibit Notch signaling in studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus, as well as in cancer cell growth, angiogenesis, and differentiation of human induced pluripotent stem cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
DAPT is used in the study of β-amyloid formation. DAPT has been shown to inhibit Notch signaling in studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus, as well as in cancer cell growth,

Chemical Identifiers

CAS 208255-80-5
Molecular Formula C23H26F2N2O4
Molecular Weight (g/mol) 432.468
MDL Number MFCD04974585
InChI Key DWJXYEABWRJFSP-XOBRGWDASA-N
Synonym dapt, dapt gsi-ix, gamma-secretase inhibitor ix, gsi-ix, insolution gamma-secretase inhibitor ix, s-tert-butyl 2-s-2-2-3,5-difluorophenyl acetamido propanamido-2-phenylacetate, n-n-3,5-difluorophenacetyl-l-alanyl-s-phenylglycine t-butyl ester, tert-butyl 2s-2-2s-2-2-3,5-difluorophenyl acetamido propanamido-2-phenylacetate, tert-butyl 2s-2-2s-2-2-3,5-difluorophenyl acetyl amino propanoyl amino-2-phenylacetate, gsiix
PubChem CID 5311272
ChEBI CHEBI:86193
IUPAC Name tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate
SMILES CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F

Specifications

Color White
Quantity 10 mg
Sensitivity Light Sensitive
Solubility Information Soluble in DMSO,ethanol,dichloromethane,DMF.
Formula Weight 432.5
Physical Form Lyophilized
Chemical Name or Material DAPT

Safety and Handling

TSCA No
Recommended Storage Store at -20°C; Store under Argon

RUO – Research Use Only