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  5. Tocris Bioscience™ CTPI 2

Tocris Bioscience™ CTPI 2

Numéro de catalogue. 779410
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Numéro de catalogue. Quantité
779410 10 mg
779450 50 mg
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Numéro de catalogue. 779410 Fournisseur Tocris Bioscience™ Code fournisseur 7794/10
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Description

Selective mitochondrial citrate transporter (SLC25A1) inhibitor

CTPI 2 is a selective mitochondrial citrate transporter (SLC25A1) inhibitor with a KD of 3.5 μM. CTPI 2 inhibits the proliferation of H1299 cells in a SLC25A1-dependent manner. It also re-sensitizes T1, T2, and T4 cells to Cisplatin (Cat. No. 2251). CTPI 2 inhibits tumor growth in in vivo models of non-small cell lung cancer (NSCLC). In high-fat diet fed mice CTPI 2 regulates glycolysis, prevents steatohepatitis and normalizes glucose tolerance and insulin sensitivity. CTPI 2 influences the inflammatory pathway by inhibiting IL-6 and TNFα production and M1 macrophage polarization.

Spécifications

Nom ou substance chimique 2-[[(4-Chloro-3-nitrophenyl)sulfonyl]amino]benzoic acid
CAS 68003-38-3
Quantité 10 mg
Cible Other Ion Pump/Transporter Inhibitors
Formule moléculaire C13H9ClN2O6S
Pureté 98%