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  5. Tocris Bioscience™ CP 43

Tocris Bioscience™ CP 43

Numéro de catalogue. 655850
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Numéro de catalogue. Quantity
655850 50 mg
655810 10 mg
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Numéro de catalogue. 655850 Fournisseur Tocris Bioscience™ Code fournisseur 6558/50*
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Description

Potent TAOK inhibitor

CP 43 is a potent TAO kinase (TAOK) inhibitor (IC50 values are 11 nM/L and 15 nM/L for TAOK1 and TAOK2, respectively). Inhibits TAOK phosphorylation and activation of JNK in vitro. Prolongs duration of mitosis and increases mitotic cell death in the SKBR3 breast cancer cell line. Also reduces tau phopshorylation in cortical neurons at sites associated with neurodegeneration in human tauopathies.

Spécifications

Chemical Name or Material N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1′-biphenyl]-4-carboxamide
CAS 850467-66-2
Quantity 50 mg
Molecular Formula C25H24N2O2
Purity 98%