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  6. Colchicine, 98%

Colchicine, 98%

Numéro de catalogue. AAJ61072ME
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Quantity:
500 mg
1 g
5 g
Numéro de catalogue. Quantity
AAJ61072ME 500 mg
AAJ6107203 1 g
AAJ6107206 5 g
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Numéro de catalogue. AAJ61072ME

Supplier: Thermo Scientific Chemicals J61072ME

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Description

Microtubule disrupting agent, and induces apoptosis in human lymphoma cells | CAS: 64-86-8 | C22H25NO6 | 399.44 g/mol

Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Solubility
Soluble in ethanol (10 mg/ml), water (45 g/L), chloroform, DMSO and methanol.

Notes
Light sensitive. Incompatible with oxidizing agents.

Identifiants chimiques

CAS 64-86-8
Molecular Formula C22H25NO6
Molecular Weight (g/mol) 399.44
MDL Number MFCD00078484,MFCD00078484
InChI Key IAKHMKGGTNLKSZ-INIZCTEOSA-N
Synonym colchicine, colchicina, colchicin, condylon, colchicinum, colchisol, colsaloid, colcin, colchineos, 7alphah-colchicine
PubChem CID 45038708
IUPAC Name 2,2,2-trideuterio-N-[(7S)-1,2,3-trimethoxy-9-oxo-10-(trideuteriomethoxy)-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
SMILES COC1=C(OC)C(OC)=C2C(CC[C@H](NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1

Spécifications

Melting Point ∽150°C (decomposition)
Color White to Yellow
Quantity 500 mg
UN Number UN1544
Beilstein 2228813
Sensitivity Light sensitive
Merck Index 14,2471
Solubility Information Soluble in ethanol (10mg/ml),water (45g/L),chloroform,DMSO and methanol.
Formula Weight 399.44
Percent Purity 98%
Physical Form Powder
Chemical Name or Material Colchicine
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Sécurité et manipulation

Hazard Category H300-H340
Hazard Statement GHS H Statement
H300-H340
Fatal if swallowed.
May cause genetic defects.
Precautionary Statement P201-P202-P264b-P270-P281-P301+P310-P308+P313-P330-P501c
DOTInformation Transport Hazard Class: 6.1; Packing Group: I; Proper Shipping Name: ALKALOIDS, SOLID, N.O.S.
EINECSNumber 200-598-5
RTECSNumber GH0700000
TSCA Yes
Recommended Storage Ambient temperatures

RUO – Research Use Only