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Tocris Bioscience™ Chloroquine diphosphate

Catalog No. 410950
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50 mg
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Catalog No. Quantity
410950 50 mg
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Catalog No. 410950 Supplier Tocris Bioscience™ Supplier No. 4109/50
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Description

Antimalarial; inhibits apoptosis and autophagy

Chloroquine diphosphate is an antimalarial drug. Inhibits cell growth and induces cell death in numerous cancer cell lines; inhibits cell proliferation and viability and induces apoptosis in 4T1 mouse breast cancer cells in vitro. Exhibits antimetastatic activity. Also inhibits autophagy via a mechanism distinct from that of 3-methyladenine (Cat. No. 3977). Blocks receptor-mediated endocytosis of mannose-glycoconjugates by macrophages. Inhibits SARS-CoV-2 infection in vitro (EC50 = 1.13 μM). Chloroquine improves efficacy of adeno-associated viral gene transduction in vivo and in vitro, as well as enhancing non-viral gene transfection in breast cancer cells. Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Chemical Identifiers

CAS 50-63-5
Molecular Formula C18H32ClN3O8P2

Specifications

Quantity 50 mg
Formula Weight 515.86
Purity >99%
Molecular Weight (g/mol) 515.86
Chemical Name or Material Chloroquine diphosphate

Safety and Handling

Recommended Storage Desiccate at Room Temperature