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Invitrogen™ CD53 Recombinant Mouse Monoclonal Antibody (161-2 (53/2))
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Numéro de catalogue. MA551887
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Quantity:
200 μg
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Numéro de catalogue. Quantity
MA551887 200 μg
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Numéro de catalogue. MA551887 Fournisseur Invitrogen™ Code fournisseur MA551887
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Description

Mouse Recombinant Monoclonal Antibody

This antibody recognizes human CD53. It does not react with the baboon and horse antigen. Cd53 is a member of tetraspanin family and is involved in cellular activation as part of a signal transduction complex involving other membrane glycoproteins.

CD53 is a tetraspanin family transmembrane glycoprotein expressed in the lymphoid-myeloid lineage. This molecule has been reported to form complexes with other leukocyte surface proteins such as CD2, CD19, CD21, MHC II, VLA-4 or tetraspanins CD37, CD81 and CD82, thus probably modulating various signaling processes. CD53 is involved in radioresistancy of tumor cells and its triggering has anti-apoptotic effect. In thymus, CD53 is up-regulated in response to positive selection signals during T cell development, and is strongly expressed upon macrophage exposure to bacterial lipopolysaccharide, whereas stimulation of neutrophils results in down-regulation of CD53 expression.

Spécifications

Antigen CD53
Applications Flow Cytometry, Functional Assay, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 161-2 (53/2)
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene Cd53
Gene Accession No. P19397
Gene Alias AI323659; antigen MOX44 identified by monoclonal antibody MRC-OX44; Cd53; CD53 antigen; CD53 glycoprotein; CD53 molecule; CD53 tetraspan antigen; cell surface antigen; cell surface glycoprotein CD53; Leukocyte antigen MRC OX-44; leukocyte surface antigen CD53; MOX44; OX44; Ox-44; tetraspanin-25; transmembrane glycoprotein; TSPAN25; tspan-25
Gene Symbols Cd53
Host Species Mouse
Immunogen This antibody was raised by immunizing mice with stimulated human leukocytes.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 963
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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