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  6. Invitrogen™ CD4 Monoclonal Antibody (RM4-5), Brilliant Ultra Violet™ 563, eBioscience™, Invitrogen™

Invitrogen™ CD4 Monoclonal Antibody (RM4-5), Brilliant Ultra Violet™ 563, eBioscience™, Invitrogen™
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Numéro de catalogue. 365004282
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Numéro de catalogue. Quantité
365004282 100 μg
365004280 25 μg
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Numéro de catalogue. 365004282 Fournisseur Invitrogen™ Code fournisseur 365004282

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Description

Rat Monoclonal Antibody

The RM4-5 mAb reacts with the mouse CD4 molecule, a 55 kDa cell surface receptor expressed by a majority of thymocytes, subpopulation of mature T cells and dendritic cells. CD4 binds to MHC class II on the surface of antigen presenting cells and plays an important role both in T cell development and in optimal functioning of mature T cells. In T cells, CD4 associates with protein tyrosine kinase p56lck through its cytoplasmic tail. Binding of RM4-5 is blocked by GK1.5. Applications Reported: This RM4-5 antibody has been reported for use in flow cytometric analysis. Applications Tested: This RM4-5 antibody has been tested by flow cytometric analysis of mouse splenocytes. This may be used at less than or equal to 0.25ug per test BUV563 is a tandem dye that emits at 564nm and is intended for use on cytometers equipped with an Ultraviolet (355nm) laser. Please make sure that your instrument is capable of detecting this fluorochrome. When using two or more Super Bright, BV, BUV, or other polymer dye-conjugated antibodies in a staining panel, it is recommended to use Super Bright Complete Staining Buffer (SB-4401-42) or Brilliant Stain Buffer (00-4409-75) to minimize any non-specific polymer interactions. Light sensitivity: This tandem dye is sensitive to photo-induced oxidation. Excitation: 350nm; Emission: 564nm; Laser: Ultraviolet Laser. BUV is a trademark or registered trademark of Becton, Dickinson and Company or its affiliates, and is used under license. Powered by Sirigen

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].

Spécifications

Antigène CD4
Applications Flow Cytometry
Classification Monoclonal
Clone RM4-5
Concentration 0.2 mg/mL
Conjugué Brilliant Ultraviolet 563
Formule PBS with BSA and 0.09% sodium azide; pH 7.2
Gène CD4
Numéro d’acquisition du gène P06332
Alias du gène Activation B7-1 antigen; B7; B7.1; B7-1; BB1; B-lymphocyte activation antigen B7; CD28LG; CD28LG1; CD4; CD4 antigen; CD4 antigen (p55); CD4 antigen p55; Cd4 molecule; CD4 precursor; CD4 receptor; CD4, allele 1; cd4a; CD4mut; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); CD80 molecule; cell surface glycoprotein CD4; costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; fCD4; L3T4; LAB7; Leu-3; Ly-4; lymphocyte antigen CD4; lymphocyte antigen CD4 precursor; membrane protein; p55; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4); T-lymphocyte activation antigen CD80; W3/25; W3/25 antigen
Symboles de gène CD4
Espèces hôtes Rat
Méthode de purification Affinity chromatography
Quantité 100 μg
Statut réglementaire RUO
Primaire ou secondaire Primary
ID du gène (Entrez) 12504
Espèces cibles Mouse
Contenu et stockage 4°C, store in dark, DO NOT FREEZE!
Type de produit Antibody
Forme Liquid
Isotype IgG2a κ
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