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MilliporeSigma™ Calbiochem™ Temozolomide

Catalog No. 5006090001
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5006090001 50mg
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Catalog No. 5006090001 Supplier MilliporeSigma™ Supplier No. 5.00609.0001
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Description

A cell-permeable, orally bioavailable, blood-brain barrier-permeant MTIC [5-(3-methyltriazen-1-yl-)-imidazole-4-carboxamide] prodrug whose in vivo DNA alkylating activity is employed in anticancer ther

A cell-permeable, orally bioavailable, blood-brain barrier-permeant MTIC [5-(3-methyltriazen-1-yl-)-imidazole-4-carboxamide] prodrug whose in vivo DNA alkylating activity is employed in anticancer therapy. MGMT ( O 6-methylguanine DNA methyl transferase) repairs TMZ-damaged DNA lesion by covalently transferring O 6-methylation on guanine residues to a cysteine residue on the MGMT, forming the basis of TMZ-resistance in cancer treatment.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Specifications

Color Off-white
Description 99% by HPLC
Target Proteins DNA guanine residues
Molecular Formula C6H6N6O2
Formula Weight 194.2g/mol
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 50 mg