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MilliporeSigma™ Calbiochem™ STING Agonist, 2ʹ3ʹ-cGAMP

Catalog No. 5318890001
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500 μg
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Catalog No. Quantity
5318890001 500 μg
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Catalog No. 5318890001 Supplier MilliporeSigma™ Supplier No. 5.31889.0001
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Description

A cyclic-dinucleotide (cyclic-GMP-AMP) based compound that binds to the C-terminal domain of adaptor endoplasmic reticulum protein known as STING with high affinity (Kd = 4nM) and induces the synthesis of interferon-b (IFN-b) in mammalian cells (EC50 =

A cyclic-dinucleotide (cyclic-GMP-AMP) based compound that binds to the C-terminal domain of adaptor endoplasmic reticulum protein known as STING with high affinity (Kd = 4nM) and induces the synthesis of interferon-b (IFN-b) in mammalian cells (EC50 = 20nM). Shown to increase IFN-b production in M2-polarized macrophages associated with non-small cell lung carcinoma and enhances the expression of M1 markers iNOS and IL-12p40, while simultaneously reducing the expression of the M2 markers, Arg-1 and Fizz1. Exhibits about 300 fold greater affinity for STING than c-DiGMP, 3′,2′-cGAMP, and 3′,3′-cGAMP and about 75 fold greater affinity over 2′,2′-cGAMP.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Specifications

Color White
Description 98% by HPLC
Target Proteins STING
Molecular Formula C20H24N10O13P2 (free acid)
Solubility H2O
Content And Storage Hygroscopic, Protect from light
Form Solid
Quantity 500 μg