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MilliporeSigma™ Calbiochem™ SKP2 E3 Ligase Inhibitor I, C1

Catalog No. 5005190001
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Catalog No.
5005190001 25mg
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Catalog No. 5005190001 Supplier MilliporeSigma™ Supplier No. 5.00519.0001
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Description

A cell-permeable rhodanine compound that upregulates cellular p21Cip1/Waf1 and p27Kip1 protein levels (10μM for 16 h in 501 Mel cultures) by preventing Skp2-Cks1-mediated substrate recruitment without affecting the F-box E3 ubiquitin ligase Skp2 interaction with Cks1 or the SCF (Skp1-cullin1-F-box) c

A cell-permeable rhodanine compound that upregulates cellular p21Cip1/Waf1 and p27Kip1 protein levels (10μM for 16 h in 501 Mel cultures) by preventing Skp2-Cks1-mediated substrate recruitment without affecting the F-box E3 ubiquitin ligase Skp2 interaction with Cks1 or the SCF (Skp1-cullin1-F-box) complex. Shown to inhibit the proliferation of human breast cancer MCF-7 and melanoma 501 Mel cells (IC50 = 8 and 30μM, respectively; 16 h incubation). Unlike SMIP004 (Cat. No. 500517), C1 does not affect cellular Cyclin E/CDK2 kinase activity or Skp2 level.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Specifications

Color Orange Brown
Description 99% by HPLC
Target Proteins disrupts p27-Skp2 interaction
Molecular Formula C18H13BrN2O4S2
Formula Weight 465.3g/mol
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 25 mg